217435-86-4

Basic information

• Product Name: 4-ethyl-4-(3-hydroxypropyl)dihydro-2(3H)-furanone
• CAS NO: 217435-86-4
• Molecular Weight: 172.224
• Mol File: 217435-86-4.mol

Chemical Properties

• CAS DataBase Reference: 4-ethyl-4-(3-hydroxypropyl)dihydro-2(3H)-furanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-4-(3-hydroxypropyl)dihydro-2(3H)-furanone(217435-86-4)
• EPA Substance Registry System: 4-ethyl-4-(3-hydroxypropyl)dihydro-2(3H)-furanone(217435-86-4)

Safety Data

• Hazardous Substances Data: 217435-86-4(Hazardous Substances Data)

Upstream product

• 217435-81-9 4-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-4-ethyl-2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester 

Downstream Products

• 217435-88-6 3-(3-Ethyl-5-methoxy-tetrahydro-furan-3-yl)-propionic acid 

Relevant articles and documents

An efficient synthesis of 4-ethyl-4-[(3-hydroxycarbonyl)propyl]dihydro- 2(3h)-furanone and its use in a formal total synthesis of (±)-quebrachamine

The Rh2(OAch)4-catalyzed reaction of diazoacetate 5 provides ready access to the pivotal cyclic acetal 13 that undergoes Pictet-Spengler-type condensation with tryptamine to directly afford an epimeric mixture of the tetracyclic lactam 17a,b. Lithium aluminum hydride reduction of 17a,b provides the known tetracyclic amino alcohol 18a,b which, overall, constitutes a formal synthesis of (±)-quebrachamine.