217446-33-8

Upstream product

• 475481-08-4 2-(4-methoxy-benzoylamino)-pent-4-enoic acid ethyl ester 
• 1203507-16-7 methyl DL-(N-(4-methoxybenzoyl))-2-amino-4-pentenoate 

Downstream Products

• 627877-65-0 4-allyl-2-(4-methoxyphenyl)oxazol-5-yl phenyl carbonate 
• 217446-36-1 4-allyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole 

Relevant academic research and scientific papers

Isothiourea-catalyzed enantioselective carboxy group transfer

Transferable skills: Enantiomerically pure isothioureas promote the 0-to C-carboxyl group transfer of oxazolyl carbonates with excellent levels of enantiocontrol (see scheme). The origin of the enantioselectivity of this process was probed mechanistically and rationalized computationally.

Oxazole derivatives

The present invention relates to novel oxazole compounds which act as PPARα and PPARγ agonists and are accordingly useful for the treatment of diseases modulated by PPARα and PPARγ such as diabetes.