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(1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-N-oxomethanaminium chloride, also known as Meldrum's acid, is a chemical compound with the molecular formula C8H11N2O2Cl. It is a stable, colorless solid that is soluble in polar organic solvents. Meldrum's acid is a versatile building block in organic synthesis and is commonly used as a reagent in the preparation of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the synthesis of heterocyclic compounds and as a catalyst in various organic reactions. Meldrum's acid has a wide range of applications in the pharmaceutical and chemical industries due to its unique structural properties and reactivity.
Used in Pharmaceutical Industry:
Meldrum's acid is used as a reagent for the preparation of various pharmaceuticals. Its unique structural properties and reactivity make it a valuable building block in the synthesis of a wide range of pharmaceutical compounds.
Used in Agrochemical Industry:
Meldrum's acid is used as a reagent in the preparation of various agrochemicals. Its versatility in organic synthesis allows for the development of new and effective agrochemical compounds.
Used in Organic Synthesis:
Meldrum's acid is used as a versatile building block in organic synthesis. Its unique structural properties and reactivity make it a valuable component in the synthesis of various organic compounds.
Used in Heterocyclic Compound Synthesis:
Meldrum's acid is used in the synthesis of heterocyclic compounds. Its ability to form stable intermediates and participate in various organic reactions makes it a useful reagent in the synthesis of heterocyclic compounds.
Used as a Catalyst in Organic Reactions:
Meldrum's acid is used as a catalyst in various organic reactions. Its unique reactivity allows it to facilitate and enhance the efficiency of a wide range of organic reactions.

21749-66-6

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21749-66-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 21749-66-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,4 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 21749-66:
(7*2)+(6*1)+(5*7)+(4*4)+(3*9)+(2*6)+(1*6)=116
116 % 10 = 6
So 21749-66-6 is a valid CAS Registry Number.

21749-66-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (1,3-dimethylbenzimidazol-2-ylidene)methyl-oxoazanium,chloride

1.2 Other means of identification

Product number -
Other names Benzimidazolium,2-formyl-1,3-dimethyl-,chloride,oxime

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21749-66-6 SDS

21749-66-6Downstream Products

21749-66-6Relevant academic research and scientific papers

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimidazolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases

Bedford,Harris III,Howd,Goff,Koolpe,Petesch,Miller,Nolen III,Musallam,Pick,Jones,Koplovitz,Sultan

, p. 493 - 503 (2007/10/02)

A series of structurally related mono- and bis-1,3-disubstituted 2-[(hydroxyimino)methyl]imidazolium halides were evaluated in vitro for their ability to reactivate electric eel, bovine, and human erythrocyte (RBC) acetylcholinesterases (AChE) inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP) and 3,3-dimethyl-2-butyl methylphosphonofluoridate (soman, GD). All new compounds were characterized for (hydroxyimino)methyl acid dissociation constant, nucleophilicity, octanol-buffer partition coefficient, reversible AChE inhibition, and kinetics of reactivation of EPMP-inhibited AChEs. For GD-inhibited AChEs, maximal reactivation was used to compare compounds since rapid phosphonyl enzyme dealkylation 'aging' complicated interpretation of kinetic constants. For comparison, we also evaluated three known pyridinium therapeutics, 2-PAM, HI-6, and toxogonin. In vivo evaluation in mice revealed that when selected imidazolium compounds were coadministered with atropine sulfate, they were effective in providing lifesaving protection against both GD and EPMP challenges. This was a major accomplishment in the search for effective anticholinesterase therapeutics - the synthesis and preliminary evaluation of the first new monoquaternary soman antidotes with potencies superior to 2-PAM. Significantly, there was an apparent inverse relationship between in vitro and in vivo results; the most potent in vivo compounds proved to be the poorest in vitro reactivators. These results suggested that an alternative and possibly novel antidotal mechanism of protective action may be applicable for the imidazolium aldoxines. Selected compounds were also evaluated for their inhibition of AChE phosphonylation by GD and antimuscarinic and antinicotinic receptor blocking effects.

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