21752-32-9 Usage
Uses
Used in Pharmaceutical Industry:
L-Methionine [S]-Sulfoximine is used as an inhibitor for glutamine synthetase, which plays a crucial role in the regulation of glutamine metabolism. Its inhibition can have therapeutic applications in cancer treatment, as cancer cells often rely on glutamine for growth and survival.
Used in Research and Development:
In the field of research and development, L-Methionine [S]-Sulfoximine serves as a valuable tool for studying the role of glutamine synthetase in various biological processes. It can be used to investigate the enzyme's function in cell signaling, metabolism, and its potential as a target for drug development.
Used in Drug Design and Synthesis:
L-Methionine [S]-Sulfoximine can be utilized in the design and synthesis of new drugs targeting glutamine synthetase. Its unique chemical properties make it a promising candidate for the development of novel therapeutic agents with improved efficacy and selectivity.
Used in Diagnostic Applications:
Due to its specificity for glutamine synthetase, L-Methionine [S]-Sulfoximine can be employed in the development of diagnostic tools and assays to detect and monitor the activity of this enzyme in various disease states, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 21752-32-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,5 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 21752-32:
(7*2)+(6*1)+(5*7)+(4*5)+(3*2)+(2*3)+(1*2)=89
89 % 10 = 9
So 21752-32-9 is a valid CAS Registry Number.
21752-32-9Relevant academic research and scientific papers
Absolute configuration of L-methionine sulfoximine as a toxic principle in Cnestis palala (Lour.) Merr.
Murakoshi,Sekine,Maeshima,Ikegami,Yoshinaga,Fujii,Okonogi
, p. 388 - 390 (2007/10/02)
An unusual amino acid, L-methionine sulfoximine (1), has been isolated from the fresh seeds of Cnestis palala (Lour.) Merr. [Connaraceae]. The absolute configuration of the natural sulfoximine (1) was confirmed to be 2(S)-methionine S(S)-sulfoximine [(2S,SS)-2-amino-4-(S-methylsulfonimidoyl)-n-butanoic acid] by comparison of the [α](D) value and IR spectrum with those of authentic samples obtained through the optical resolution of synthetic materials. Acute toxicity of the seeds of C. palala in a beagle dog was also studied.
QUANTITATIVE SEPARATION AND ANALYSIS OF DIASTEREOMERS OF L-METHIONINE-S,R-SULFOXIMINE VIA CYCLIC N-BLOCKED DERIVATIVES
Sugiyama, Yuichi,Wedler, Frederick C.
, p. 1471 - 1474 (2007/10/02)
The diastereomers of L-methionine-S,R-sulfoximine, blocked at α-N with phthaloyl, then cyclized with Ac2O to form 3,4,5,6-tetrahydro-1-methyl-3-oxo-4-(N-phthalimido)-1,2-thiazine-1-oxide, could be easily separated by fractional crystallization or HPLC, whereas the parent compounds were very difficult to separate.
