21752-35-2

Basic information

• Product Name: (R)-(+)-N-(1-PHENYLETHYL)PHTHALAMIC ACID
• Synonyms: (R)-(+)-N-(1-PHENYLETHYL)PHTHALAMIC ACID;(R)-(+)-N-(1-METHYLBENZYL)PHTHALIC ACID MONOAMIDE;(R)(+)-ALPHA-PHENETHYLPHTHALAMIC ACID;(R)-(+)-(ALPHA-METHYLBENZYL)PHTHALAMIC ACID;(R)-(+)-(1-PHENYLETHYL)PHTHALAMIC ACID;(R)-(1-PHENYLETHYL)PHTHALAMIC ACID;(+)-N-(1-PHENYLETHYL)PHTHALIC ACID MONOAMIDE;(R)-(+)-N-(alpha-Methylbenzyl)phthalamic acid
• CAS NO: 21752-35-2
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.3
• EINECS: 244-570-0
• Product Categories: for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry
• Mol File: 21752-35-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 128-130 °C
• Boiling Point: 500.3 °C at 760 mmHg
• Flash Point: 256.3 °C
• Appearance: /
• Density: 1.222 g/cm³
• Vapor Pressure: 7.92E-11mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• BRN: 5793588
• CAS DataBase Reference: (R)-(+)-N-(1-PHENYLETHYL)PHTHALAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-(1-PHENYLETHYL)PHTHALAMIC ACID(21752-35-2)
• EPA Substance Registry System: (R)-(+)-N-(1-PHENYLETHYL)PHTHALAMIC ACID(21752-35-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 21752-35-2(Hazardous Substances Data)

Usage

Uses

Acid for the resolution of amines.

InChI:InChI=1/C16H15NO3/c1-11(12-7-3-2-4-8-12)17-15(18)13-9-5-6-10-14(13)16(19)20/h2-11H,1H3,(H,17,18)(H,19,20)/t11-/m1/s1

Upstream product

• 85-44-9 phthalic anhydride 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Downstream Products

• 1213771-63-1 (-)-(8S)-2-{(E)-2-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]vinyl}-8-(2-trifluoromethylphenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 2306-33-4 monoethyl phthalate 

Relevant articles and documents

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PROCESS FOR ENANTIOMERIC ENRICHMENT OF 2 ', 6 ' - PIPECOLOXYLIDIDE

The invention discloses a process for enantiomeric enrichment of 2',6'-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel intermediates formed in the process of enantiomeric enrichment of 2',6'-pipecoloxylidide, preparation of N- substituted amidic acids and alkylation of 2',6'-pipecoloxylidide.