21752-36-3

Basic information

• Product Name: (S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID
• Synonyms: (S)-(-)-N-(1-Phenylethyl)phthalamic acid 97%;(S)-(-)-N-(α2-{[(1S)-1-Phenylethyl]carbamoyl}benzoic acid;(S)-(1-PHENYLETHYL)PHTHALAMIC ACID;(S)(-)-ALPHA-PHENETHYLPHTHALAMIC ACID;(S)-(-)-N-(ALPHA-METHYLBENZYL)PHTHALAMIC ACID;(S)-(-)-N-(ALPHA-METHYLBENZYL)PHTHALAMIDIC ACID;(S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID
• CAS NO: 21752-36-3
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.3
• EINECS: 244-571-6
• Product Categories: Chiral Building Blocks;Glycidyl Compounds, etc. (Chiral);Synthetic Organic Chemistry
• Mol File: 21752-36-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 128-130 °C
• Boiling Point: 500.263 °C at 760 mmHg
• Flash Point: 256.35 °C
• Appearance: /
• Density: 1.223 g/cm³
• Vapor Pressure: 7.92E-11mmHg at 25°C
• Refractive Index: -46 ° (C=2, EtOH)
• Storage Temp.: Store below +30°C.
• Solubility: very faint turbidity in Methanol
• BRN: 3210897
• CAS DataBase Reference: (S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID(21752-36-3)
• EPA Substance Registry System: (S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID(21752-36-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 21752-36-3(Hazardous Substances Data)

Usage

Description

(S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID, also known as N-phenylethylphthalamic acid, is a synthetic compound that belongs to the phthalamic acid derivatives. It is recognized for its potential applications in research and industry due to its diverse biological activities. This chiral compound is particularly noted for its use in the resolution of enantiomers and as a building block in the synthesis of specialized chemicals. Additionally, it has garnered interest for its potential antiviral and antibacterial properties, although further research is necessary to elucidate its full spectrum of applications and mechanisms of action.

Uses

Used in Pharmaceutical Research:
(S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID is used as a chiral resolving agent for the separation of enantiomers, which is crucial in pharmaceutical development where the biological activity of each enantiomer may differ significantly.
Used in Chemical Synthesis:
In the chemical industry, (S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID serves as a building block for the synthesis of other specialized chemicals, contributing to the creation of novel compounds with specific applications.
Used in Antiviral and Antibacterial Research:
(S)-(-)-N-(1-PHENYLETHYL)PHTHALAMIC ACID is studied for its potential antiviral and antibacterial properties, indicating its possible use in the development of new treatments for viral and bacterial infections. Further research is required to confirm its efficacy and safety in these applications.

InChI:InChI=1/C16H15NO3/c1-11(12-7-3-2-4-8-12)17-15(18)13-9-5-6-10-14(13)16(19)20/h2-11H,1H3,(H,17,18)(H,19,20)/t11-/m0/s1

Upstream product

• 85-44-9 phthalic anhydride 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Relevant articles and documents

PROCESS FOR ENANTIOMERIC ENRICHMENT OF 2 ', 6 ' - PIPECOLOXYLIDIDE

The invention discloses a process for enantiomeric enrichment of 2',6'-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel intermediates formed in the process of enantiomeric enrichment of 2',6'-pipecoloxylidide, preparation of N- substituted amidic acids and alkylation of 2',6'-pipecoloxylidide.