21753-44-6Relevant academic research and scientific papers
Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris
Pettit, George R.,Knight, John C.,Herald, Delbert L.,Pettit, Robin K.,Hogan, Fiona,Mukku, Venugopal J. R. V.,Hamblin, John S.,Dodson II, Michael J.,Chapuis, Jean-Charles
experimental part, p. 366 - 371 (2009/12/25)
Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10-4-10-5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.
