21775-50-8Relevant academic research and scientific papers
Hydrogen peroxide-promoted metal free oxidative amidation of 2-oxoaldehydes: A facile access to unsymmetrical oxamides
Zhan, Zhen,Cheng, Xu,Ma, Xiaojun,Li, Jie,Hai, Li,Wu, Yong
, p. 6928 - 6934 (2015/08/24)
A novel and green H2O2-promoted oxidative amidation of 2-oxoaldehydes with amines to synthesize unsymmetrical oxamides has been developed. The reactions proceeded smoothly at room temperature under metal-free conditions and generated the corresponding products in good yields. This methodology has a broad substrate scope and opens up an interesting and attractive avenue for the synthesis of unsymmetrical oxamide derivatives.
