21780-68-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a key component in the development of new drugs and agricultural products.
Used in Petroleum Industry:
In the petroleum industry, N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is employed as a corrosion inhibitor. Its application helps to prevent the corrosion of pipelines and storage tanks, thereby extending their service life and reducing maintenance costs.
Used in Biological Research:
N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea has been studied for its potential biological activities, such as its role as an anti-inflammatory agent. This research is crucial for understanding its effects on various biological pathways and its potential use in the development of new therapeutic agents.
Used in Environmental Protection:
Due to its potential hazards to human health and the environment, N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is also used in the development of strategies for environmental protection and safety measures to minimize its impact on ecosystems and human populations.

InChI:InChI=1/C13H13N3OS/c1-17-11-7-5-10(6-8-11)15-13(18)16-12-4-2-3-9-14-12/h2-9H,1H3,(H2,14,15,16,18)

Upstream product

• 504-29-0 2-aminopyridine 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 69437-82-7 2-(4-Anisyl)-3-(2'-pyridyl)-thiazolidin-4-on 
• 78755-05-2 1-(4-methoxyphenyl)-3-(2-pyridyl)thiobarbiturate 
• 79834-34-7 3-Amino-5-p-methoxyphenylimino-4-(2-pyridyl)-4,5-dihydro-1,2,4-thiadiazole 

Relevant academic research and scientific papers

Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions

An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.

I2-Catalyzed Oxidative N-S Bond Formation: Metal-Free Regiospecific Synthesis of N-Fused and 3,4-Disubstituted 5-Imino-1,2,4-thiadiazoles

A novel and expeditious approach for the synthesis of N-fused and 3,4-disubstituted 5-imino-1,2,4-thiadiazole derivatives has been achieved through the molecular iodine-catalyzed oxidative cyclization of 2-aminopyridine/amidine and isothiocyanate via N-S

Corrosion-protective properties of 1-phenacylmethyl-2- arylcarbamido(arylthiocarbamido)pyridinium bromides

Inhibiting effect of 1-phenacylmethylpyridinium bromides containing urea or thiourea substituents in the pyridinium ring on steel and zinc corrosion in sulfuric acid solutions was studied.

Structural and spectral studies of N-(2-pyridyl)-N′-(4-substituted phenyl)thioureas

The following molecules were found to have intramolecular hydrogen bonding between the N′H and the pyridine nitrogen and intermolecular hydrogen bonding between the NH and a thione sulfur of a second molecule to form dimers: N-(2-pyridyl)-N′-(4-methoxyphe

Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones

[N-(2-pyridyl)-N'-(4-(un) substituted] thioureas and (substitutedaryl)thiosemicarbazones were synthesised and evaluated for their antibacterial activity. All aryl thiosemicarbazones showed good activity against Aeromonas hydrophilia and Salmonella typhimuriurn. But none of the pyridyl thioureas showed any prominent activity against tested bacteria.

Interactions between substituted thioureas and π-acceptors

Charge-transfer (CT) interactions between some N-aryl-N'-heterocyclic thioureas and both tetracyanoethylene (TCNE) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) were investigated spectroscopically. The formed CT complexes and the solvent effect on CT complexation are discussed. N-Aryl-N'-(2-pyridyl)-thioureas 1 a-d reacted with TCNE to give cyanothiourea derivatives 6, however in case of DDQ, the adducts 7 were obtained.

Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates

Eight 1-aryl-3-(2-pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20-60% protection against pentylenetetrazol-induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD50 values which were found to range from 500-1000 mg/kg. All substituted thiobarbiturates (1mM) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10-72%.