21780-68-7

Basic information

• Product Name: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea
• Synonyms: 1-(p-Methoxyphenyl)-3-(2-pyridyl)thiourea;N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea;1-(4-METHOXYPHENYL)-3-(2-PYRIDYL)-2-THIOUREA
• CAS NO: 21780-68-7
• Molecular Formula: C₁₃H₁₃N₃OS
• Molecular Weight: 259.3268
• Mol File: 21780-68-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 145 °C
• Boiling Point: 407.4°Cat760mmHg
• Flash Point: 200.2°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 7.57E-07mmHg at 25°C
• Refractive Index: 1.721
• PKA: 11.27±0.70(Predicted)
• CAS DataBase Reference: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea(21780-68-7)
• EPA Substance Registry System: N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea(21780-68-7)

Safety Data

• Hazardous Substances Data: 21780-68-7(Hazardous Substances Data)

Usage

General Description

N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea is a chemical compound with the molecular formula C13H12N4OS. It is a white to off-white solid that is used in various industrial applications, including as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a corrosion inhibitor in the petroleum industry. N-(2-Pyridyl)-N'-(4-methoxyphenyl)thiourea has been studied for its potential biological activities, including its role as an anti-inflammatory agent and its effects on various biological pathways. It is important to handle this compound with caution, as it may be hazardous to human health and the environment.

InChI:InChI=1/C13H13N3OS/c1-17-11-7-5-10(6-8-11)15-13(18)16-12-4-2-3-9-14-12/h2-9H,1H3,(H2,14,15,16,18)

Upstream product

• 504-29-0 2-aminopyridine 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 69437-82-7 2-(4-Anisyl)-3-(2'-pyridyl)-thiazolidin-4-on 
• 79834-34-7 3-Amino-5-p-methoxyphenylimino-4-(2-pyridyl)-4,5-dihydro-1,2,4-thiadiazole 
• 78755-05-2 1-(4-methoxyphenyl)-3-(2-pyridyl)thiobarbiturate 

Relevant articles and documents

Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions

An efficient synthesis of thiazolidine-2,4,5-triimine derivatives was developed via Ni-catalyzed oxidative double isocyanide insertion to thioureas under air conditions, in which thioureas play three roles as a substrate, a ligand, and overcoming isocyanide polymerization. The reaction is featured by employing a low-cost and low loading Ni(acac)2 catalyst, without any additives, and high atom economy. This is the first example to directly apply a Ni(II) catalyst in oxidative double isocyanide insertion reactions.

Corrosion-protective properties of 1-phenacylmethyl-2- arylcarbamido(arylthiocarbamido)pyridinium bromides

Inhibiting effect of 1-phenacylmethylpyridinium bromides containing urea or thiourea substituents in the pyridinium ring on steel and zinc corrosion in sulfuric acid solutions was studied.

Synthesis and antibacterial activity of pyridyl thioureas and arylthiosemicarbazones

[N-(2-pyridyl)-N'-(4-(un) substituted] thioureas and (substitutedaryl)thiosemicarbazones were synthesised and evaluated for their antibacterial activity. All aryl thiosemicarbazones showed good activity against Aeromonas hydrophilia and Salmonella typhimuriurn. But none of the pyridyl thioureas showed any prominent activity against tested bacteria.