217805-63-5Relevant academic research and scientific papers
The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements
Nordhoff, Sonja,Bulat, Stephan,Cerezo-Galvez, Silvia,Hill, Oliver,Hoffmann-Enger, Barbara,Lopez-Canet, Meritxell,Rosenbaum, Claudia,Rummey, Christian,Thiemann, Meinolf,Matassa, Victor G.,Edwards, Paul J.,Feurer, Achim
scheme or table, p. 6340 - 6345 (2010/06/11)
For a series of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes.
Synthesis of chiral pyrazoles and isoxazoles as constrained amino acids
Falorni, Massimo,Giacomelli, Giampaolo,Spanedda, Anton Mario
, p. 3039 - 3046 (2007/10/03)
A stereospecific syntheses of optically active pyrazoles and isoxazoles from L-proline is described. The procedure presented is based on readily available materials and can be used for preparing new conformationally restricted pyrazole-containing amino ac
