217805-63-5 Usage
Class
Pyrazole
Structure
A phenyl and pyrrolidinyl group attached to a central pyrazole ring
Therapeutic potential
Treatment of central nervous system disorders such as anxiety, depression, and schizophrenia
Mechanism of action
Modulation of certain neurotransmitters in the brain
Research status
Ongoing to explore its pharmacological properties and potential as a medication for various neurological and psychiatric conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 217805-63-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,7,8,0 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 217805-63:
(8*2)+(7*1)+(6*7)+(5*8)+(4*0)+(3*5)+(2*6)+(1*3)=135
135 % 10 = 5
So 217805-63-5 is a valid CAS Registry Number.
217805-63-5Relevant articles and documents
The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements
Nordhoff, Sonja,Bulat, Stephan,Cerezo-Galvez, Silvia,Hill, Oliver,Hoffmann-Enger, Barbara,Lopez-Canet, Meritxell,Rosenbaum, Claudia,Rummey, Christian,Thiemann, Meinolf,Matassa, Victor G.,Edwards, Paul J.,Feurer, Achim
scheme or table, p. 6340 - 6345 (2010/06/11)
For a series of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractive pharmacokinetic profile and show excellent efficacy in an animal model of diabetes.
