217811-63-7

Basic information

• Product Name: methyl 2-chloro-4-methylpyridine-3-carboxylate
• Synonyms: methyl 2-chloro-4-methylpyridine-3-carboxylate;Methyl 2-chloro-4-Methylnicotinate;2-Chloro-4-methyl-nicotinic acid methyl ester
• CAS NO: 217811-63-7
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.60762
• Mol File: 217811-63-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 258.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.247±0.06 g/cm3(Predicted)
• PKA: -0.59±0.10(Predicted)
• CAS DataBase Reference: methyl 2-chloro-4-methylpyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chloro-4-methylpyridine-3-carboxylate(217811-63-7)
• EPA Substance Registry System: methyl 2-chloro-4-methylpyridine-3-carboxylate(217811-63-7)

Safety Data

• Hazardous Substances Data: 217811-63-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-chloro-4-methylpyridine-3-carboxylate is a chemical compound with the molecular formula C8H8ClNO2. It is a derivative of pyridine and belongs to the class of organic compounds known as pyridine carboxylic acids. methyl 2-chloro-4-methylpyridine-3-carboxylate is commonly used as a reagent in organic synthesis and pharmaceutical research. It is also used in the production of various pharmaceuticals, agrochemicals, and fine chemicals. Methyl 2-chloro-4-methylpyridine-3-carboxylate is known to have potential biological and pharmacological activities, making it an important component in the field of medicinal chemistry. It is important to handle this chemical with caution as it may pose hazards to human health and the environment.

Upstream product

• 73583-37-6 2-chloro-4-bromopyridine 
• 142266-63-5 2-chloro-4-methyl-3-pyridinecarboxylic acid 
• 74-88-4 methyl iodide 
• 185041-05-8 2-chloro-4-iodonicotinic acid methyl ester 
• 544671-78-5 2-chloro-4-iodo-3-pyridinecarboxylic acid 
• 153034-86-7 2-chloro-4-iodopyridine 
• 1064678-14-3 methyl 4-bromo-2-chloronicotinate 
• 544-97-8 dimethyl zinc(II) 

Downstream Products

• 142266-63-5 2-chloro-4-methyl-3-pyridinecarboxylic acid 
• 447402-10-0 (2-chloro-4-methyl-pyridin-3-yl)-methanol 

Relevant articles and documents

THIOETHER-PIPERIDINYL OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to thioether-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thioether-piperidinyl compounds described herein in the potential treatment or prevention

Novel small molecule bradykinin B2 receptor antagonists

Blockade of the bradykinin B2 receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B2 receptor antagonists with a molecular weight of approximately 500 g/mol. First, known quinoline-based B2 receptor antagonists were stripped down to their shared core motif 53, which turned out to be the minimum pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B2 receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B2 receptor. Optimization of the microsomal stability and cytochrome P450 inhibition eventually led to the discovery of the highly potent and orally available B2 receptor antagonist 52e (JSM10292), which showed the best overall properties.