217811-63-7

Usage

Uses

Used in Pharmaceutical Research:
Methyl 2-chloro-4-methylpyridine-3-carboxylate is used as a reagent in pharmaceutical research for the development of new drugs and pharmaceuticals. Its unique chemical structure and potential biological activities make it a valuable component in the discovery and synthesis of novel therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, methyl 2-chloro-4-methylpyridine-3-carboxylate is used in the production of various agrochemicals. Its application in this field contributes to the development of effective and innovative products for agricultural and pest control purposes.
Used in Fine Chemicals Synthesis:
Methyl 2-chloro-4-methylpyridine-3-carboxylate is also utilized in the synthesis of fine chemicals, which are high-purity, specialty chemicals used in various industries such as cosmetics, fragrances, and flavorings. Its versatility and potential applications make it an important compound in the fine chemicals market.
Used in Medicinal Chemistry:
Due to its potential biological and pharmacological activities, methyl 2-chloro-4-methylpyridine-3-carboxylate is used in medicinal chemistry for the development of new therapeutic agents and drug candidates. Its unique properties and reactivity make it a promising component in the advancement of medical treatments and interventions.

Upstream product

• 73583-37-6 2-chloro-4-bromopyridine 
• 142266-63-5 2-chloro-4-methyl-3-pyridinecarboxylic acid 
• 74-88-4 methyl iodide 
• 185041-05-8 2-chloro-4-iodonicotinic acid methyl ester 
• 544671-78-5 2-chloro-4-iodo-3-pyridinecarboxylic acid 
• 153034-86-7 2-chloro-4-iodopyridine 
• 1064678-14-3 methyl 4-bromo-2-chloronicotinate 
• 544-97-8 dimethyl zinc(II) 

Downstream Products

• 142266-63-5 2-chloro-4-methyl-3-pyridinecarboxylic acid 
• 447402-10-0 (2-chloro-4-methyl-pyridin-3-yl)-methanol 

Relevant academic research and scientific papers

THIOETHER-PIPERIDINYL OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to thioether-piperidinyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the thioether-piperidinyl compounds described herein in the potential treatment or prevention

MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF

The present disclosure provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of preparing these compounds.

Novel small molecule bradykinin B2 receptor antagonists

Blockade of the bradykinin B2 receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B2 receptor antagonists with a molecular weight of approximately 500 g/mol. First, known quinoline-based B2 receptor antagonists were stripped down to their shared core motif 53, which turned out to be the minimum pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B2 receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B2 receptor. Optimization of the microsomal stability and cytochrome P450 inhibition eventually led to the discovery of the highly potent and orally available B2 receptor antagonist 52e (JSM10292), which showed the best overall properties.

8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS

The present invention is related to compound of the formula (I): or a pharmacologically acceptable salt, solvate, or hydrate thereof, wherein A is a 6-membered heteroaryl having from 1 to 3 heteroatoms, each independently selected from N or O and the other substituents are defined as in the claims.