217824-07-2Relevant academic research and scientific papers
A general asymmetric route to trans- or cis.2,6-disubstituted piperidine. First total synthesis of (+)-9-epi-6-epipinidinol and (-)- pinidinol
Takahata, Hiroki,Yotsui, Yasuhito,Momose, Takefumi
, p. 13505 - 13516 (2007/10/03)
Starting from 1,6-heptadiene, two AD reactions in a stepwise manner lead to the anti-1,5-diol and syn-1,5-diol stereodivergently, which have been converted by aminocyclization into trans- and cis-2,6-disubstituted piperidines (trans- and cis-12), respectively. The first total synthesis of (+)-9-epi-6-epipinidinol (2) and (-)-pinidinol (3) has been achieved from trans- and cis-12.
