21792-87-0

Usage

Uses

Used in Pharmaceutical Industry:
5-chloro-2-nitrobenzenesulfonyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its reactivity allows for the formation of sulfonyl chlorides, which are essential in the creation of a wide range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 5-chloro-2-nitrobenzenesulfonyl chloride serves as an intermediate in the production of agrochemicals, including pesticides and herbicides. Its role in the synthesis of these compounds helps to improve agricultural productivity and crop protection.
Used in Dye Industry:
5-chloro-2-nitrobenzenesulfonyl chloride is utilized as a building block in the synthesis of dyes, contributing to the development of new colorants for various applications, such as textiles, plastics, and printing inks.
Used in Organic Synthesis:
As a versatile acylating agent, 5-chloro-2-nitrobenzenesulfonyl chloride is used in organic synthesis for the preparation of a variety of organic compounds. Its reactivity enables the formation of sulfonyl chlorides, which are important intermediates in the synthesis of complex organic molecules.

Upstream product

• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 132749-58-7 N-(2-bromophenyl)-2-nitro-5-chlorobenzenesulfonamide 
• 173908-26-4 1-(5-Chloro-2-nitro-benzenesulfonyl)-1H-indole 
• 173908-15-1 1-(5-Chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 173908-20-8 1-(5-Chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid 2-diethylamino-ethyl ester 
• 173908-27-5 1-(5-Chloro-2-nitro-benzenesulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 173908-17-3 1-(5-Chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid isopropyl ester 
• 173908-18-4 1-(5-Chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid allyl ester 
• 311807-80-4 1-[(5-chloro-2-nitrophenyl)sulfonyl]-2-trichloroacetyl-1H-pyrrole 
• 184090-53-7 N-benzyl,N-methyl 1-[(5-chloro-2-nitrophenyl)sulfonyl]-1H-pyrrole-2-carboxyamide 
• 184090-25-3 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid sec-butyl ester 
• 685563-15-9 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid 2-methoxy-ethyl ester 
• 184090-31-1 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester 
• 184090-28-6 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopentyl ester 
• 184090-29-7 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclohexyl ester 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of fo

Novel benzopyridothiadiazepines as potential active antitumor agents

The synthesis of novel thiadiazepine derivatives, that could be considered as constraint analogues of E-7010, are reported. These molecules were evaluated for their antiproliferative activity toward the murine L1210 leukemia cell line. Flow cytometric studies performed on L1210 cells with the most cytotoxic compounds showed an accumulation of the cells in the G2/M phases of the cell cycle with a significant percentage of tetraploid cells (8N DNA content). Submicromolar cytotoxicities were observed with compounds 2b, 4b, 4e, 4g, and 4i. Two of them, compounds 2b and 4b, were found to be potent inhibitors of tubulin polymerization with IC50 of respectively 3.8 and 2.4 μM compared to 2.4 μM for desoxypodophyllotoxin. A 4-methoxyphenylethyl substitution on the pyridinyl nitrogen of the benzopyridothiadiazepine was found to be essential for the antiproliferative activity. The in vitro activities of compounds 2b and 4b make benzopyridothiadiazepine dioxides a promising new class of tubulin binders which warrant further in vivo evaluation.