217970-19-9Relevant academic research and scientific papers
Conformationally constrained inhibitors of caspase-1 (interleukin-1β converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, APOPAIN)
Karanewsky, Donald S.,Bai, Xu,Linton, Steven D.,Krebs, Joseph F.,Wu, Joe,Pham, Bryan,Tomaselli, Kevin J.
, p. 2757 - 2762 (1998)
A systematic study of interleukin-1β converting enzyme (ICE, caspase- 1) and caspase-3 (CPP32, apopain) inhibitors incorporating a P2-P3 conformationally constrained dipeptide mimetic is reported. Depending on the nature of the P4 substituent, highly selective inhibitors of both Csp-1 or Csp-3 were obtained.
