2180-05-4Relevant articles and documents
Thiazoles and thiopyridines: Novel series of high affinity h5HT 7 ligands
Thomson, Christopher G.,Beer, Margaret S.,Curtis, Neil R.,Diggle, Helen J.,Handford, Emma,Kulagowski, Janusz J.
, p. 677 - 680 (2007/10/03)
A series of thiazole based 5HT7 ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT7 ligands, the most active of which behaves as a partial agonist.
Synthesis of potential plant protecting compounds on the basis of 2,3-dihydrothiazol-2-thione. I. Change in structure at the N3 and C4
Hanefeld, Wolfgang,Wurtz, Stephan
, p. 355 - 370 (2007/10/03)
A considerable number of potential plant protecting compounds with the core structure of 2,3-dihydrothiazol-2-thione has been prepared by the reaction of dithiocarbamates with halomethylcarbonyl compounds forming N-substituted 4-substituted 4-hydroxythiazolidin-2-thiones 2-4, which can split off water to yield 5. The structural variability at N3 is given either by the amine used for dithiocarbamate synthesis or by acylation of N-unsubstituted 2,3-dihydrothiazol-2-thiones like 4i. The variability at C4 is either achieved by the kind of the halomethylcarbonyl compound or by reactions of 4:chloromethyl derivatives 5, which can be transformed by a number of nucleophilic reagents to derivatives like thioethers 8, ethers 9, amines 10, nitriles 11, azides 12a, thiocyanates 12b, the primary amine 14 and derived from that the amides 15 or the ureas 16. Wiley-VCH Verlag GmbH, 2000.
