21801-86-5

Basic information

• Product Name: 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE
• Synonyms: 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE;Imidazo(1,2-a)pyridine-3-acetamide;3-(Carbamoylmethyl)imidazo(1,2-A)pyridine;Brn 1568679;Imidazo(1,2-A)pyridine, 3-(carbamoylmethyl)-
• CAS NO: 21801-86-5
• Molecular Formula: C9H9N3O
• Molecular Weight: 175.18726
• Mol File: 21801-86-5.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.34 g/cm³
• Refractive Index: 1.672
• PKA: 15.52±0.40(Predicted)
• CAS DataBase Reference: 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE(21801-86-5)
• EPA Substance Registry System: 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE(21801-86-5)

Safety Data

• Hazardous Substances Data: 21801-86-5(Hazardous Substances Data)

Usage

General Description

2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE is a chemical compound with the molecular formula C10H9N3O. It is a heterocyclic compound that contains both imidazole and pyridine rings, and is classified as an amide due to the presence of the acetamide functional group. 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE has potential pharmaceutical and therapeutic applications, as it may have biological activity in the treatment of certain diseases or medical conditions. Its precise uses and effects are still being researched and studied, but its unique structure and properties make it an interesting candidate for further investigation in the field of medicinal chemistry.

InChI:InChI=1/C9H9N3O/c10-8(13)5-7-6-11-9-3-1-2-4-12(7)9/h1-4,6H,5H2,(H2,10,13)

Upstream product

• 504-29-0 2-aminopyridine 
• 142-08-5 2-hydroxypyridin 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 
• 101820-69-3 imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester 

Downstream Products

• 17745-04-9 imidazo<1,2-a>pyridin-3-acetic acid 
• 603288-22-8 LY2090314 
• 603281-60-3 LY2090314 

Relevant articles and documents

Preparation method of minodronic acid key intermediate

The invention belongs to the technical field of drug synthesis, and provides a preparation method of a minodronic acid key intermediate. The method comprises the following steps: reacting ethyl 4-chloroacetoacetate with an ammonia organic solution to obtain a compound V, and reacting the compound V with a compound IV under the catalysis of a [Cu] catalyst to obtain a compound III imidazo[1,2-a]pyridine-3-acetamide; and hydrolyzing the compound III with concentrated hydrochloric acid to obtain a compound II imidazo[1,2-a]pyridine-3-acetic acid. The method has the advantages that the reaction conditions are simple, the raw material utilization degree is high, the yield is high, the purity is high, the pollution to the environment is small, and the method is suitable for industrial production.

Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines

Practical and scalable procedures for Minodronic acid and Zolpidem are developed with short reaction sequences from 2-aminopyridines and maleic anhydride, respectively. The new procedures avoid column chromatography for the purification in all synthetic steps. Key aspects of this development involve reductive hydrodechlorination and Suzuki coupling reaction of 2-chloroimidazole[1,2-a]pyridines, and their application towards synthesis of the two drugs is also addressed.

1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS

The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.