21801-89-8 Usage
General Description
3-Carbamoyl-2-methylimidazo(1,2-a)pyridine, also known as CMIP, is a chemical compound that is commonly found in cooked meats and is formed during the high-temperature cooking of animal products. It is classified as a heterocyclic amine and is considered to be a potential carcinogen. CMIP is formed from the reaction of creatinine, a natural compound found in muscle tissue, with the amino acid proline during the cooking process. Research has shown that CMIP has genotoxic and mutagenic properties, and exposure to this compound has been associated with an increased risk of certain cancers, particularly colorectal cancer. Therefore, efforts to reduce exposure to CMIP in the diet, such as by using lower cooking temperatures and avoiding charred or well-done meats, are recommended to reduce the potential health risks associated with this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 21801-89-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,8,0 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21801-89:
(7*2)+(6*1)+(5*8)+(4*0)+(3*1)+(2*8)+(1*9)=88
88 % 10 = 8
So 21801-89-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H9N3O/c1-6-8(9(10)13)12-5-3-2-4-7(12)11-6/h2-5H,1H3,(H2,10,13)
21801-89-8Relevant articles and documents
2-Aminopyridines as an α-Bromination Shuttle in a Transition Metal-Free One-Pot Synthesis of Imidazo[1,2-a]pyridines
Roslan, Irwan Iskandar,Ng, Kian-Hong,Chuah, Gaik-Khuan,Jaenicke, Stephan
supporting information, p. 364 - 369 (2016/04/26)
A wide range of imidazo[1,2-a]pyridines are accessible from cheap and readily available 2-aminopyridines and 1,3-dicarbonyl compounds using a unique CBrCl3/2-aminopyridine system for bromination at the α-carbon. 2-Aminopyridine is not only the substrate but also acts as a bromination shuttle, transferring the bromine atom from CBrCl3 to the α-carbon of the 1,3-dicarbonyl. The reaction mechanism involves a series of reversible steps, including an addition reaction with cyclic transition state, to form a bromo-hemiaminal intermediate. Isolated yields of up to 97% were obtained under mild conditions and at short reaction times in this transition metal-free, one-pot synthesis.
