21803-75-8

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H5ClN2/c8-6-3-5(4-9)1-2-7(6)10/h1-3H,10H2

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 53312-88-2 N-(2-chloro-4-cyanophenyl)acetamide 
• 34662-29-8 1-chloro-5-cyano-2-nitrobenzene 

Downstream Products

• 34662-29-8 1-chloro-5-cyano-2-nitrobenzene 
• 178804-10-9 4-benzothiazol-2-yl-2-chlorophenylamine 
• 2486-71-7 4-amino-3-chlorobenzoic acid 
• 795300-37-7 4-[4-(butyl-ethyl-amino)-6-methyl-3-nitro-pyridin-2-ylamino]-3-chloro-benzonitrile 
• 887510-99-8 3-chloro-4-(4-dipropylamino-6-methyl-3-nitro-pyridin-2-ylamino)-benzonitrile 
• 856888-94-3 3-chloro-4-[4-(cyclobutylmethyl-propyl-amino)-6-methyl-3-nitro-pyridin-2-ylamino]-benzonitrile 
• 50961-67-6 4-amino-3-chlorobenzamide 
• 1261686-46-7 3-chloro-4-iodobenzonitrile 
• 911124-37-3 4-amino-3-chloro-5-iodo-benzonitrile 
• 945391-06-0 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 253863-32-0 C₆₁H₆₉ClN₆O₂₀ 
• 205448-68-6 4-amino-3-(benzyloxy)benzonitrile 
• 402714-30-1 3-chloro-4-isothiocyanatobenzonitrile 
• 372192-42-2 2-chloro-4-(1H-tetrazol-5-yl)phenylamine 

Relevant academic research and scientific papers

Iron(III)-Catalyzed Chlorination of Activated Arenes

A general and regioselective method for the chlorination of activated arenes has been developed. The transformation uses iron(III) triflimide as a powerful Lewis acid for the activation of N-chlorosuccinimide and the subsequent chlorination of a wide range of anisole, aniline, acetanilide, and phenol derivatives. The reaction was utilized for the late-stage mono- and dichlorination of a range of target compounds such as the natural product nitrofungin, the antibacterial agent chloroxylenol, and the herbicide chloroxynil. The facile nature of this transformation was demonstrated with the development of one-pot, tandem, iron-catalyzed dihalogenation processes allowing highly regioselective formation of different carbon-halogen bonds. The synthetic utility of the resulting dihalogenated aryl compounds as building blocks was established with the synthesis of natural products and pharmaceutically relevant targets.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES

Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride

A novel, efficient Fe/CaCl2 system is revealed for the reduction of nitroarenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation (CTH). The selective reduction of nitro compounds in the presence of sensitive functional groups including halides, carbonyl, hydroxyl, aldehyde, methyl, methoxy, acetyl, nitrile, and ester substituents with an excellent yields is reported. The simple experimental procedure and easy purification make the protocol advantageous

Preparation of fully substituted anilines for the synthesis of functionalized indoles

A wide range of highly functionalized indoles were prepared by the successive magnesiation of readily available o-alkynyl protected anilines using TMPMgCl·LiCl or LDA, followed by a KH-mediated cyclization reaction.

Practical and efficient chlorination of deactivated anilines and anilides with NCS in 2-propanol

Deactivated anilines and anilides were efficiently monochlorinated with NCS in 2-propanol. The described method was applicable to a large scale synthesis.

Anthelmintically active benzenepropanamide derivatives

This invention is directed to a method for treating helminthiasis in an animal which method comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of the Formula (I): STR1 wherein Z is oxygen or sulfur;R 1 is hydrogen or lower alkyl; andR 2, R 3, R 4 and R 5 are independently hydrogen, halo, lower haloalkyl, lower alkoxy, lower haloalkoxy, nitro, cyano, halophenoxy, haloalkylphenoxy, thiocyano or isothiocyano, provided that R 2 and R 3 cannot simultaneously be hydrogen and that R 4 and R 5 cannot simultaneously be hydrogen; or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions formulated therewith. This invention is also directed to novel anthelmintically active benzenepropanamides of Formula (I) wherein Z is oxygen.

Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same

This invention relates to new alkane-sulfonanilide derivatives of the formula: STR1 wherein R1, R2 and R8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy, R3 is lower alkyl, R4 is acyl, cyano, carboxy, hydroxy(lower)-alkyl, mercapto, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, 5-membered unsaturated heterocyclic group which may have amino, lower alkanoylamino, lower alkylthio or lower alkylsulfonyl, phenylthio which may have nitro or amino, lower alkanoyl(lower)alkenyl or a group of the formula: STR2 wherein R6 is hydrogen, amino or lower alkyl and R7 is hydroxy, lower alkoxy, carboxy(lower)alkoxy, lower alkoxycarbonyl(lower)alkoxy, ureido or thioureido, and R5 is hydrogen, halogen, lower alkyl or lower alkanoyl, and pharmaceutically acceptable salts thereof. More particularly, it relates to alkanesulfonanilide derivatives and pharmaceutically acceptable salts thereof which have antiinflammatory activities and analgesic activities, to processes for the preparation thereof, to a pharmaceutical composition comprising the same and to a method for the treatment of inflammatory disease or pains in human being and animals".

Succinimido azo dyestuffs

The invention relates to water-insoluble azo dyestuffs of the formula SPC1 In which A represents the residue of a diazo component of the azobenzene series, R1 a hydrogen atom or an alkyl group which may be substituted which may be substituted, R2 an alkyl group which may be substituted, R3 represents a divalent organic residue which together with the grouping EQU1 may form a 5- to 7-membered heterocycle, and X represents a hydrogen atom or an alkyl, alkoxy, aryloxy or arylmercapto group. The dyestuffs dye polyester fibre in orange, red or blue shades with good fastness: the use of such succinimido containing azo dyestuffs in imparting blue to red color to fibers or fabrics of wool, cellulose triacetate, polyamides and polyesters. The dyeings display excellent fastness to light, sublimation and abrasion on polyester fibers.