21805-71-0

Basic information

• Product Name: 2,6-bis(aziridin-1-yl)-2,6-dimethylheptan-4-one
• Synonyms: 2,6-Bis(1-aziridinyl)-2,6-dimethyl-4-heptanone; 4-Heptanone, 2,6-bis(1-aziridinyl)-2,6-dimethyl-
• CAS NO: 21805-71-0
• Molecular Formula: C₁₃H₂₄N₂O
• Molecular Weight: 224.3425
• Mol File: 21805-71-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 310.3°C at 760 mmHg
• Flash Point: 116.6°C
• Density: 1.088g/cm³
• Vapor Pressure: 0.000605mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 2,6-bis(aziridin-1-yl)-2,6-dimethylheptan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-bis(aziridin-1-yl)-2,6-dimethylheptan-4-one(21805-71-0)
• EPA Substance Registry System: 2,6-bis(aziridin-1-yl)-2,6-dimethylheptan-4-one(21805-71-0)

Safety Data

• Hazardous Substances Data: 21805-71-0(Hazardous Substances Data)

Usage

Description

2,6-bis(aziridin-1-yl)-2,6-dimethylheptan-4-one, commonly known as Melphalan, is a synthetic alkylating agent derived from nitrogen mustard. It is a potent chemotherapy drug that primarily targets the disruption of cancer cell growth and proliferation. Classified as an extremely hazardous substance, Melphalan requires careful handling to prevent adverse health effects.

Uses

Used in Oncology:
Melphalan is utilized as a chemotherapeutic agent for the treatment of various malignancies, such as multiple myeloma, ovarian cancer, and melanoma. It functions by alkyating and cross-linking DNA strands, thereby inhibiting the replication and division of cancer cells, leading to their eventual death.
Used in Stem Cell Transplantation:
Melphalan is employed as a conditioning treatment prior to stem cell transplantation. Its alkylating properties allow for the effective suppression of the patient's immune system, creating a conducive environment for the engraftment of transplanted stem cells and reducing the risk of graft-versus-host disease.
Used in Drug Delivery Systems:
To enhance the therapeutic efficacy and minimize the side effects of Melphalan, various drug delivery systems have been developed. These systems, including liposomes and nanoparticles, aim to improve the drug's bioavailability, target specificity, and overall safety profile.
Despite its potential toxicity and side effects, such as nausea, vomiting, diarrhea, and hair loss, Melphalan remains an essential component in cancer treatment regimens. Its use should always be supervised by a healthcare professional to ensure optimal patient safety and therapeutic outcomes.