21809-08-5Relevant academic research and scientific papers
2 Aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazines, a new class of antidepressants
Greenwood,Mallion,Todd,Turner
, p. 573 - 577 (2007/10/05)
Some 2 aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazines have been shown to possess marked antidepressant activity. The 1,4 oxazines were synthesized by lithium aluminium hydride reduction of the readily available 6 aryloxymethyl 2,3,5,6 tetrahydro 1,4 oxazin 3 ones. High antidepressant activity was associated with ortho substitution of the 2 phenoxymethyl group and with 1,4 oxazines devoid of 4 substituents.
