21814-48-2

Upstream product

• 50-30-6 2,6-dichlorobenzoic acid 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 
• 55776-09-5 6-chloro-2-<(4-methoxyphenyl)amino>-3-nitrobenzoic acid 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 99008-57-8 9-methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-ethanamine 
• 99008-55-6 N,N-diethyl-9-methoxy-5-nitropyrazolo<3,4,5-kl>acridine-2(6H)-ethanamine 
• 99009-20-8 Pyrazoloacridine 
• 99009-21-9 Pyrazoloacridine methanesulfonate 
• 134039-84-2 1-chloro-7-methoxy-4-nitro-9-phenoxyacridine 
• 134039-82-0 9-amino-7-methoxy-4-nitro-1-phenoxyacridine 

Relevant academic research and scientific papers

Structure-activity relationship of novel acridone derivatives as antiproliferative agents

Unlike other DNA topoisomerase II (topo II) inhibitors, our recently identified acridone derivative E17 exerted strong cytotoxic activity by inhibiting topo II without causing topo II degradation and DNA damage, which promoted us to explore more analogues

Novel inhibitors of NRH:Quinone oxidoreductase 2 (NQO2): Crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones

Imidazoacridin-6-ones are shown to be potent nanomolar inhibitors of the enzyme NQO2. By use of computational molecular modeling, a reliable QSAR was established, relating inhibitory potency with calculated binding affinity. Further, crystal structures of

Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2

A range of triazoloacridin-6-ones functionalized at C5 and C8 have been synthesized and evaluated for ability to inhibit NQO1 and NQO2. The compounds were computationally docked into the active site of NQO1 and NQO2, and calculated binding affinities were

2-(Aminoalkyl)-5-nitropyrazoloacridines, a New Class of Anticancer Agents

2-(Aminoalkyl)-5-nitropyrazoloacridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.

Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them

Substituted 1-amino-4-nitroacridinones, their method of manufacture, pharmaceutical compositions and their use as antibacterial and antitumor agents are herein described.

Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use

Pyrazolo[3,4,5-kl]acridines are described as antibacterial agents and antitumor agents as well as pharmaceutical compositions and methods for their preparation.