218151-48-5 Usage
Uses
Used in Medicinal Chemistry:
1H-Indene-1,2-diamine,2,3-dihydro-,(1R,2R)-(9CI) is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and stereochemistry allow for the development of novel drugs with specific biological activities.
Used in Drug Development:
1H-Indene-1,2-diamine,2,3-dihydro-,(1R,2R)-(9CI) is utilized in drug development as a potential therapeutic agent. Its amine groups can be modified to create new molecules with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Organic Synthesis:
1H-Indene-1,2-diamine,2,3-dihydro-,(1R,2R)-(9CI) serves as a versatile intermediate in organic synthesis. Its reactivity and functional groups can be exploited to synthesize a wide range of organic compounds, including natural products, agrochemicals, and specialty chemicals.
Used in Chiral Chemistry:
The specific stereochemistry of 1H-Indene-1,2-diamine,2,3-dihydro-,(1R,2R)-(9CI) makes it a valuable compound in chiral chemistry. It can be used as a chiral auxiliary or a chiral ligand in asymmetric synthesis, enabling the preparation of enantiomerically pure compounds with high selectivity.
Used in Research:
1H-Indene-1,2-diamine,2,3-dihydro-,(1R,2R)-(9CI) is employed in research to study the effects of stereochemistry on the biological activity of molecules. It can also be used as a model compound to investigate the reactivity and selectivity of various chemical reactions, providing insights into the fundamental principles of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 218151-48-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,1,5 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 218151-48:
(8*2)+(7*1)+(6*8)+(5*1)+(4*5)+(3*1)+(2*4)+(1*8)=115
115 % 10 = 5
So 218151-48-5 is a valid CAS Registry Number.
218151-48-5Relevant academic research and scientific papers
Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins
Yuan, Yong-An,Lu, Deng-Fu,Chen, Yun-Rong,Xu, Hao
, p. 534 - 538 (2016/02/27)
Reported herein is a new iron-catalyzed diastereoselective olefin diazidation reaction which occurs at room temperature (1-5 mol % of catalysts and d.r. values of up to >20:1). This method tolerates a broad range of both unfunctionalized and highly functionalized olefins, including those that are incompatible with existing methods. It also provides a convenient approach to vicinal primary diamines as well as other synthetically valuable nitrogen-containing building blocks which are difficult to obtain with alternative methods. Preliminary mechanistic studies suggest that the reaction may proceed through a new mechanistic pathway in which both Lewis acid activation and iron-enabled redox-catalysis are crucial for selective azido-group transfer. With iron hand: The title reaction proceeds at room temperature and tolerates a broad range of both unfunctionalized and highly functionalized olefins. It also provides a convenient synthetic approach to a variety of nitrogen-containing building blocks. Preliminary mechanistic studies suggest both Lewis acid activation and iron-enabled redox catalysis are crucial for the selective azido-group transfer.
Synthesis of enantiomerically pure cis- and trans-1,2- diaminoindanes
Bit, Christelle,Mitrochkine, Anton A.,Gil, Gerard,Pierrot, Marcel,Reglier, Marius
, p. 3263 - 3273 (2007/10/03)
The four isomers of cis- and trans-1,2-diaminoindanes 5 and 11 were prepared in three steps and high enantiomeric excess by a key lipase- catalyzed selective transesterification of racemic cis-2-azido-1-indanol and trans-1-azido-2-indanol, respectively.
