218151-56-5 Usage
Uses
Used in Pharmaceutical Research:
1H-Indene-1,2-diamine,2,3-dihydro-,(1S,2R)-(9CI) is utilized as a key intermediate in the synthesis of various pharmaceuticals, leveraging its reactivity and structural features to create new drug candidates. Its ability to form different derivatives through chemical reactions makes it a valuable component in the development of innovative medications.
Used in Organic Synthesis:
As a building block in organic synthesis, 1H-Indene-1,2-diamine,2,3-dihydro-,(1S,2R)-(9CI) is employed to construct complex organic molecules. Its capacity for undergoing reduction, acylation, and alkylation reactions enables the synthesis of a broad range of organic compounds, contributing to the advancement of material science and chemical research.
Used in Asymmetric Synthesis:
The enantiopure form of 1H-Indene-1,2-diamine,2,3-dihydro-,(1S,2R)-(9CI) is applied in asymmetric synthesis to produce enantiomerically pure compounds. This is crucial in pharmaceutical development, as the different enantiomers of a drug can exhibit distinct biological activities and pharmacokinetics.
Used in Organometallic Chemistry:
1H-Indene-1,2-diamine,2,3-dihydro-,(1S,2R)-(9CI) also serves as a ligand in organometallic chemistry, facilitating the creation of metal complexes with unique catalytic properties. These complexes are vital in various chemical transformations, further expanding the utility of 1H-Indene-1,2-diamine,2,3-dihydro-,(1S,2R)-(9CI) in the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 218151-56-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,1,5 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 218151-56:
(8*2)+(7*1)+(6*8)+(5*1)+(4*5)+(3*1)+(2*5)+(1*6)=115
115 % 10 = 5
So 218151-56-5 is a valid CAS Registry Number.
218151-56-5Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of ketones using amino alcohol and monotosylated diamine derivatives of indane
Palmer, Matthew J.,Kenny, Jennifer A.,Walsgrove, Tim,Kawamoto, Aparecida M.,Wills, Martin
, p. 416 - 427 (2007/10/03)
A series of 1,2-amino alcohol and 1,2-monotosylated diamine derivatives of indane have been applied as ligands in the asymmetric ruthenium(II)-catalysed transfer hydrogenation reaction of a series of ketones. Of these, the cis-1-aminoindan-2-ol derivative gives some of the highest asymmetric inductions reported for any amino alcohol ligand in this application.
Synthesis of enantiomerically pure cis- and trans-1,2- diaminoindanes
Bit, Christelle,Mitrochkine, Anton A.,Gil, Gerard,Pierrot, Marcel,Reglier, Marius
, p. 3263 - 3273 (2007/10/03)
The four isomers of cis- and trans-1,2-diaminoindanes 5 and 11 were prepared in three steps and high enantiomeric excess by a key lipase- catalyzed selective transesterification of racemic cis-2-azido-1-indanol and trans-1-azido-2-indanol, respectively.
