21816-07-9

Upstream product

• 61065-68-7 3-Phenyl-1-adamantanol 
• 780-68-7 1-phenyladamantane 
• 132317-54-5 (E)-5-Phenyl-2-adamantanespirooxirane 
• 132317-54-5 (Z)-5-Phenyl-2-adamantanespirooxirane 
• 132317-54-5 5-Phenyl-2-adamantanespirooxirane 

Downstream Products

• 67496-94-0 1-Ethoxy-3-phenyl-adamantan 
• 120952-43-4 1-(4-hydroxyphenyl)-3-phenyladamantane 

Relevant academic research and scientific papers

ADAMANTANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION

Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.

ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION

Compounds of structural Formula (I) were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus.

Electronic Control of Face Selection in the Capture of Radicals

A simple procedure is described which leads to the pure epimeric 2-(5-phenyl)adamantanecarboxylic acids E-1 and Z-1.Both acids upon treatment with bromine and mercuric oxide in carbon tetrachloride undergo the Hunsdiecker reaction to give the same mixture of E- and Z-2-bromo-5-phenyladamantanes 4. 5-Phenyl-2-methyleneadamantane 6 undergoes reaction with bromotrichloromethane to give two diastereomeric adducts.In both instances, the major isomer results from the abstraction of a bromine atom by the zu face of the intermediate 5-phenyl-2-adamantyl radicals.The results mesh with other examples of face selection which have previously ascribe d to transitions state hyperconjugation.In additional case (hydride shift in a carbocation) was encountered in this work, as well as one apparent exception: the oxirane formation from adamantanone and sulfonium ylids.That result is attributed to thermodynamic control of the initial addition step.

Adamantane derivatives in the prevention and treatment of cerebral ischemia

A method for the prevention and treatment of cerebral ischemia using an adamantane derivative of the formula STR1 wherein R1 and R2 are identical or different, representing hydrogen or a straight or branched alkyl group of 1 to 6 C atoms or, in conjunction with N, a heterocyclic group with 5 or 6 ring C atoms; wherein R3 and R4 are identical or different, being selected from hydrogen, a straight or branched alkyl group of 1 to 6 C atoms, a cycloalkyl group with 5 or 6 C atoms, and phenyl; wherein R5 is hydrogen or a straight or branched C1 -C6 alkyl group, or a pharmaceutically-acceptable salt thereof, is disclosed.