21816-08-0

Basic information

• Product Name: 3-Bromoadamantane-1-carboxylic acid
• Synonyms: 3-broMo-adaMantaine-1-carboxylic acid;1-BroMo-3-carboxyadaMantane;1-BroMoadaMantane-3-carboxylic acid;3-Bromotricyclo[3.3.1.1~3,7~]decane-1-carboxylic acid, 1-Bromo-3-carboxyadamantane;3-BroMoadaMantane-1-carboxylic acid;3-Bromoadamantane-1-carboxylic acid 97%;3-ADAMANTANECARBOXYLIC ACID, 1-BROMO-;Tricyclo(3.3.1.1(sup 3,7))decane-1-carboxylic acid, 3-bromo- (9CI)
• CAS NO: 21816-08-0
• Molecular Formula: C₁₁H₁₅BrO₂
• Molecular Weight: 259.14
• Product Categories: Organic Building Blocks;Adamantane derivatives;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis
• Mol File: 21816-08-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 147 °C
• Boiling Point: 354.2 °C at 760 mmHg
• Flash Point: 168 °C
• Appearance: /
• Density: 1.665 g/cm³
• Vapor Pressure: 5.69E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 4.35±0.40(Predicted)
• CAS DataBase Reference: 3-Bromoadamantane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromoadamantane-1-carboxylic acid(21816-08-0)
• EPA Substance Registry System: 3-Bromoadamantane-1-carboxylic acid(21816-08-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• RTECS: AU4452500
• HazardClass: IRRITANT
• Hazardous Substances Data: 21816-08-0(Hazardous Substances Data)

Usage

Uses

3-Bromo-1-adamantane Carboxylic Acid is used in the synthesis and in bioactivity of novel adamantyl derivatives, as potent MDR reversal agents.

Purification Methods

Purify the acid by recrystallising it from cyclohexane and/or subliming at 130o/10mm. It is converted to the methyl ester (diazomethane) with m 32o (from pet ether at -10o). [Stetter & Mayer Chem Ber 95 667 1962, Stetter & Wulff Chem Ber 93 1366 1960, Bayal & Lantvoev J Org Chem USSR (Engl Trans) 9 291 1973.]

InChI:InChI=1/C11H15BrO2/c12-11-4-7-1-8(5-11)3-10(2-7,6-11)9(13)14/h7-8H,1-6H2,(H,13,14)/p-1/t7-,8-,10?,11?/m1/s1

Upstream product

• 42711-75-1 3-hydroxyadamantane-1-carboxylic acid 
• 50795-82-9 3-nitroxyadamantane-1-carboxylic acid 
• 42711-78-4 3-acetoxyadamantane-1-carboxylic acid 
• 828-51-3 1-Adamantanecarboxylic acid 

Downstream Products

• 39269-10-8 adamantane-1,3-dicarboxylic acid 
• 56531-56-7 3-(4-methoxyphenyl)adamantane-1-carboxylic acid 
• 27983-08-0 bromo-3 adamantylcarboxylate de methyle 
• 88358-11-6 3-(4-Fluorophenyl)-1-adamantanecarboxylic acid 
• 88358-12-7 3-(4-Methylthiophenyl)-1-adamantanecarboxylic acid 
• 96962-78-6 3-Fluor-1-adamantancarbonsaeurefluorid 
• 126164-71-4 3-(4-hydroxy-2-methylphenyl)adamantanecarboxylic acid 
• 56531-69-2 3-p-Tolyl-adamantane-1-carboxylic acid 
• 37589-22-3 3-phenyl-adamantane-1-carboxylic acid 
• 876-53-9 1,3-dibromoadamantane 
• 702-82-9 3-aminoadamantan-1-ol 

Relevant articles and documents

Investigation of the gas phase reactivity of the 1-adamantyl radical using a distonic radical anion approach

The gas phase reactions of the bridgehead 3-carboxylato-1-adamantyl radical anion were observed with a series of neutral reagents using a modified electrospray ionisation linear ion trap mass spectrometer. This distonic radical anion was observed to undergo processes suggestive of radical reactivity including radical-radical combination reactions, substitution reactions and addition to carbon-carbon double bonds. The rate constants for reactions of the 3-carboxylato-1-adamantyl radical anion with the following reagents were measured (in units 10-12 cm3 molecule-1 s -1): 18O2 (85 ± 4), NO (38.4 ± 0.4), I2 (50 ± 50), Br2 (8 ± 2), CH 3SSCH3 (12 ± 2), styrene (1.20 ± 0.03), CHCl3 (H abstraction 0.41 ± 0.06, Cl abstraction 0.65 ± 0.1), CDCl3 (D abstraction 0.035 ± 0.01, Cl abstraction 0.723 ± 0.005), allyl bromide (Br abstraction 0.53 ± 0.04, allylation 0.25 ± 0.01). Collision rates were calculated and reaction efficiencies are also reported. This study represents the first quantitative measurement of the gas phase reactivity of a bridgehead radical and suggests that distonic radical anions are good models for the study of their elusive uncharged analogues. The Royal Society of Chemistry.

METHODS OF INDUCING AN ANTI-CANCER IMMUNE RESPONSE

A method or preparing immunologically primed cancer cells using cancer cells collected from a patient includes treating the collected cancer cells, ex vivo, with a toxic concentration of a compound that modifies sphingolipid metabolism, wherein the toxic concentration is sufficient to induce immunogenic cell death in the cancer cells. In an embodiment, the compound is 3-(4-Chloro-phenyl)-adamantane-1-carboxylic acid(pyridin-4-ylmethyl)-amide compound or a pharmaceutically acceptable salt thereof. In an embodiment, the immunologically primed cancer cells overexpress calreticulin on their surface. In an embodiment, the cancer cells are solid tumor cells. In an embodiment, the cancer cells are circulating tumor cells. In an embodiment, the method further comprises harvesting at least a portion of the immunologically primed cancer cells; and suspending the cells in phosphate-buffered saline. In an embodiment, the method further comprises shipping at least a portion of the immunologically primed cancer cells to a point of the patient's care.

Azido-Adamantyl Tin Sulfide Clusters for Bioconjugation

We present a new versatile route toward biomolecule-functionalized tin sulfide clusters. A novel bifunctional orthogonal spacer was developed and used for the formation of a trifold azido-adamantyl-terminated cluster, serving as a building block for click reactions. The azido cluster was quantitatively bioconjugated via a strain-promoted 1,3-dipolar cycloaddition, affording a peptide-decorated cluster.