2182-78-7

Basic information

• Product Name: 4-(Benzothiazol-2-yl)benzoic acid
• Synonyms: Benzoicacid, p-2-benzothiazolyl- (7CI,8CI); 4-(Benzothiazol-2-yl)benzoic acid
• CAS NO: 2182-78-7
• Molecular Formula: C₁₄H₉NO₂S
• Molecular Weight: 255.29
• Mol File: 2182-78-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 465.0±47.0 °C(Predicted)
• Appearance: /
• Density: 1.386±0.06 g/cm3(Predicted)
• PKA: 3.91±0.10(Predicted)
• CAS DataBase Reference: 4-(Benzothiazol-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Benzothiazol-2-yl)benzoic acid(2182-78-7)
• EPA Substance Registry System: 4-(Benzothiazol-2-yl)benzoic acid(2182-78-7)

Safety Data

• Hazardous Substances Data: 2182-78-7(Hazardous Substances Data)

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 1431880-66-8 C₁₀H₁₁NO₄ 
• 105-07-7 4-cyanobenzaldehyde 
• 17930-02-8 2-(4'-cyanophenyl)benzothiazole 
• 2182-77-6 2-(4-methoxycarbonylphenyl)benzothiazole 
• 18708-46-8 terephthaloyl chloride 

Downstream Products

• 879894-25-4 2-(4-carboxyphenyl)-6-nitrobenzothiazole 
• 1030513-24-6 4-benzothiazol-2-yl-benzoic acid ethyl ester 
• 1154058-63-5 4-Benzothiazol-2-yl-N-(2-sulfamoylphenyl)sulfonyl-benzamide 
• 2182-80-1 4-(benzo[d]thiazol-2-yl)benzaldehyde 
• 2182-79-8 4-benzothiazol-2-yl-benzoyl chloride 

Relevant articles and documents

Fluorine-containing benzothiazole as a novel trypanocidal agent: Design, in silico study, synthesis and activity evaluation

Trypanosoma cruzi (T. cruzi) is the etiologic agent of Chagas disease. In the bloodstream of humans, this parasite is in the trypomastigote stage and can infect host cells. Its metabolism is dependent on the glycolysis pathway, and one enzyme important fo

Method for preparing benzothiazole compound through microwave catalysis in water phase

The invention discloses a method for preparing a benzothiazole compound through/under microwave catalysis in a water phase. A water-soluble coordination compound is used as a catalyst, and a reactionof inorganic sulfide, 2-iodoaniline and aldehyde is efficiently catalyzed through microwaves in a pure water phase. The method for preparing the benzothiazole compound is environmentally friendly, convenient to operate, safe, cheap and efficient. Compared with the prior art, the method is applied to a large quantity of functional groups, high in yield, simple to operate, safe, low in cost and environmentally friendly and produces a few byproducts.

Weinreb amide as an efficient reagent in the one pot synthesis of benzimidazoles and benzothiazoles

One pot synthesis of 2-substituted benzimidazoles/benzothiazoles through condensation is followed by cyclization of Weinreb amide with o-diaminoarene or o-aminothiophenol is reported. In the presence of boron trifluoride etherate in 1,4-dioxane solvent, a high yield (75-94%) was achieved within 60 min. Weinreb amide shows high selectivity in the reaction, even in presence of other active functional groups such as carboxyl, halogen, cyano, and methoxy.