21820-08-6Relevant academic research and scientific papers
Synthesis of a benzo[b]-1,5-naphthyridine derivative as a potential constrained NK1 receptor antagonist
Viti, Giovanni,Giannotti, Danilo,Nannicini, Rossano,Balacco, Giuseppe,Pestellini, Vittorio
, p. 5939 - 5942 (1994)
A short synthesis of a cyclic constrained analogue 1 of the potent Substance P antagonist (±) CP-96345 is described. The key feature is the formation of the benzo[b]-1,5-naphthyridine system at the very last step of the synthesis through an intramolecular arylation of an amine promoted by a strong base. If the tricyclic system was synthesized first, 2-methoxy benzylation of both the nitrogen atoms occurred.
