21821-06-7Relevant academic research and scientific papers
A novel synthesis of a 1,3-disubstituted 1,3-dihydro-2H-imidazo[4,5-b] pyridin-2-one. Application to GW808990 a CRF1 receptor antagonist
Hayes, Jerome F.,Popkin, Matthew E.
experimental part, p. 297 - 303 (2011/04/24)
A novel synthesis of a 1,3-disubstituted 1,3-dihydro-2H-imidazo-[4,5-b] pyridin-2-one has been achieved by condensation of iminohydantoin 3 with t-butyl acetoacetate in diglyme at 160 °C. Hydrogenation of the product in the presence of 4-heptanone followed by a Buchwald-Hartwig amination afforded GW808990, a CRF1 receptor antagonist. The Japan Institute of Heterocyclic Chemistry.
