218269-00-2Relevant academic research and scientific papers
Binreduction of (R)-carvone and regioselective baeyer-villiger oxidations: Application to the asymmetric synthesis of cryptophycin fragment A
Varie, David L.,Brennan, John,Briggs, Barbara,Cronin, Jason S.,Hay, David A.,Rieck III, John A.,Zmijewski, Milton J.
, p. 8405 - 8408 (2007/10/03)
Cryptophycin fragment A (1) was prepared in high enantiomeric purity in 10 steps from (R)-carvone. A stereoselective bioreduction of (R)-carvone to neodihydrocarveol and a regioselective Baeyer-Villiger oxidation of cyclohexanone 8 with pertrifluoroacetic acid were employed in this synthesis.
