218288-72-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-bromo-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)is used as a pharmaceutical compound for its potential medicinal properties. The carboxylic acid and phenylacetylamino groups present in the molecule may contribute to its interaction with biological targets, such as enzymes or receptors, making it a candidate for the development of new drugs. Its specific stereochemistry, being (6R,7R)configured, may also play a crucial role in determining its efficacy and selectivity in biological systems.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-bromo-8-oxo-7-[(phenylacetyl)amino]-, diphenylmethyl ester, (6R,7R)serves as a valuable research tool for studying the structure-activity relationship of drug candidates. Its unique functional groups and stereochemistry allow scientists to investigate the effects of these features on the compound's biological activity, potentially leading to the discovery of more effective and selective therapeutic agents.

Upstream product

• 122553-60-0 (6R,7R)-benzhydryl 8-oxo-7-(2-phenylacetamido)-3-(((trifluoromethyl)sulfonyl)oxy)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 395661-00-4 diphenylmethyl (6R, 7R)-7-phenylacetamido-3-[(S)-tetrahydrofuran-2-yl]ceph-3-em-4-carboxylate 
• 371207-62-4 (R)-3-Bromo-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 460739-54-2 (R)-3-Bromo-8-oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-58-8 (R)-3-Bromo-7,8-dioxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 371207-54-4 (6R,7R)-7-Amino-3-bromo-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Convenia synthetic method and Convenia sodium salt synthetic method

The invention discloses a Convenia synthetic method and a Convenia sodium salt synthetic method. A ceftizoxime sodium midbody is taken as the raw material and is subjected to bromination, electrophilic addition, nucleophilic substitution, deprotection, amidation and the like to obtain Convenia and Convenia sodium salt. According to the Convenia synthetic method, synthetic routes and steps are simplified through technology improvement and reaction condition improvement, and cost is saved. The Convenia synthetic method and the Convenia sodium salt synthetic method are easy to operate, mild in reaction condition, low in requirement for production equipment, and capable of creating sound conditions for industrialization. It shows through analysis and detection that a prepared product is high in quality and can meet the requirements of industrial and agricultural production.

Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.

New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases.

Coupling reactions of cephalosporin sulfones: A stable 3-stannylated cephem

matrix presented The first stable 3-metalated cephalosporin is reported and shown to be an excellent synthetic precursor to a number of prospective β-lactamase inhibitors.