21829-15-2

Basic information

• Product Name: diethyl 4-(4-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: 3,5-Pyridinedicarboxylic acid, 4-(4-aminophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
• CAS NO: 21829-15-2
• Molecular Formula: C₁₉H₂₄N₂O₄
• Molecular Weight: 344.4049
• Mol File: 21829-15-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 499.5°C at 760 mmHg
• Flash Point: 255.9°C
• Density: 1.164g/cm³
• Vapor Pressure: 4.13E-10mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: diethyl 4-(4-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-(4-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(21829-15-2)
• EPA Substance Registry System: diethyl 4-(4-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(21829-15-2)

Safety Data

• Hazardous Substances Data: 21829-15-2(Hazardous Substances Data)

Upstream product

• 7165-13-1 acetic butyric anhydride 
• 555-16-8 4-nitrobenzaldehdye 
• 141-97-9 ethyl acetoacetate 
• 21881-54-9 2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Downstream Products

• 1384460-67-6 diethyl 4-(4-(3-(2-chloro-5-(trifluoromethyl)phenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-68-7 diethyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido) phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-69-8 diethyl 4-(4-(3-(3,4-dichlorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-70-1 diethyl 4-(4-(3-(2,5-dichlorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-71-2 diethyl 4-(4-(3-(2,4-dichlorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-72-3 diethyl 2,6-dimethyl-4-(4-(3-(4-(trifluoromethyl) phenyl)ureido) phenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-73-4 diethyl 4-(4-(3-(4-chlorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-74-5 diethyl 4-(4-(3-(4-fluorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-75-6 diethyl 4-(4-(3-(4-cyanophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1384460-76-7 diethyl 4-(4-(3-(2,5-difluorophenyl)ureido)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Design, synthesis, spectral characterization and molecular docking studies of novel pyranoquinolinyl dihydropyridine carboxylates as potential antibacterial agents including Vibrio cholerae with minimal cytotoxity towards fibroblast cell line (L-929)

Novel pyranoquinolinyl dihydropyridine carboxylate (PDC) derivatives were designed by incorporating the multi-drug resistance modulating effects of 1,4 dihydropyridines along with potential antibacterial activity of quinolines in the molecular design. The

Synthesis and pharmacological evaluation of novel homocamptothecin- dihydropyridine derivative conjugates as potent topoisomerase i inhibitors

Homocamptothecins (hCPT) represent a new generation of antitumour agents targeting DNA topoisomerase I. The expanded seven-membered lactone E-ring that characterizes hCPT enhances the plasma stability of the drug and reinforces the inhibition of topoisomerase I (Topo I) compared with conventional six-membered CPT. In an attempt to improve the antitumour activity of hCP, a series of novel hCPT derivatives conjugating with dihydropyridine derivates were designed and synthesized based on a synthetic route that couples 7-formylhomocamptothecin with different dihydropyridine derivates. Most of the synthesized compounds exhibited good cytotoxic activity on tumour cell line A549, MDA-MB-435, and HCT116. Furthermore, this class of compounds showed superior Topo I inhibition activity comparable to or higher than CPT. CSIRO 2011.