218292-41-2

Upstream product

• 218292-35-4 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(4-fluoro-phenyl)-butane-1,2-diol 
• 29123-91-9 3-(4-fluorophenyl)-3-buten-1-ol 
• 218292-32-1 tert-Butyl-[3-(4-fluoro-phenyl)-but-3-enyloxy]-dimethyl-silane 
• 218292-28-5 methyl 3-(4-fluorophenyl)-3-butenoate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 82511-02-2 ((3-bromobut-3-en-1-yl)oxy)(tert-butyl)dimethylsilane 
• 1131-77-7 3-(4-fluorophenyl)-3-butenoic acid 

Relevant academic research and scientific papers

An efficient synthesis of enantiomerically pure 2-[(2R)-arylmorpholin- 2-yl]ethanols, key intermediates of tachykinin receptor antagonist

We report herein an efficient and practical synthetic method for the preparation of enantiomerically pure 2[(2R)-arylmorpholin-2-yl]ethanols 1a- d, key intermediates of tachykinin receptor antagonist. Sharpless catalytic asymmetric dihydroxylation of 4a-d was employed to introduce the required absolute stereochemistry, and cyclization of 7a-d was accomplished by the Mitsunobu reaction.