218301-47-4

Basic information

• Product Name: 2-FLUORO-5-(5-FURAN-2-YL-3-TRIFLUORO-METHYL-PYRAZOL-1-YL)-BENZONITRILE
• Synonyms: 2-FLUORO-5-(5-FURAN-2-YL-3-TRIFLUORO-METHYL-PYRAZOL-1-YL)-BENZONITRILE
• CAS NO: 218301-47-4
• Molecular Formula: C₁₅H₇F₄N₃O
• Molecular Weight: 321.2291928
• Mol File: 218301-47-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-FLUORO-5-(5-FURAN-2-YL-3-TRIFLUORO-METHYL-PYRAZOL-1-YL)-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-(5-FURAN-2-YL-3-TRIFLUORO-METHYL-PYRAZOL-1-YL)-BENZONITRILE(218301-47-4)
• EPA Substance Registry System: 2-FLUORO-5-(5-FURAN-2-YL-3-TRIFLUORO-METHYL-PYRAZOL-1-YL)-BENZONITRILE(218301-47-4)

Safety Data

• Hazardous Substances Data: 218301-47-4(Hazardous Substances Data)

Upstream product

• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 53312-81-5 3-cyano-4-fluoroaniline 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 557-21-1 dicyanozinc 

Downstream Products

• 1051930-23-4 2-fluoro-5-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzaldehyde 
• 540510-46-1 [1-(4-{[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl]-amino}-3-fluoro-phenyl)-1H-imidazol-2-ylmethyl]-methyl-carbamic acid benzyl ester 
• 540510-45-0 benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate 
• 540510-50-7 N-[4-[(2-t-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 1026874-23-6 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(3-tert-butylsulfamoyl-pyridin-4-yl)-2-fluoro-phenyl]-amide 
• 540510-49-4 N-[4-[(2-tert-butyldimethylsilyloxymethyl)-1H-imidazol-1-yl]-2-fluorophenyl]-1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 754193-52-7 1-(3'-cyano-4'-fluorophenyl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-pyrrolidin-1-ylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide 
• 218298-94-3 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[2-fluoro-4-(N-pyrrolidinocarbonyl)phenyl-aminocarbonyl]pyrazole 
• 540510-52-9 2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-azidomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide 
• 540510-51-8 2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [4-(2-bromomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide 
• 209960-59-8 1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-[(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-pyrazole 

Relevant articles and documents

HUMAN PLASMA KALLIKREIN INHIBITORS

Disclosed are compounds of formula (I), as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Novel N-[4- (1H-imidazol-1-yl) -2-fluorophenyl ] -3- (trifluoromethyl) -1H-pyrazole-5-carboxamides as factor Xa inhibitors

The present application describes N-[4-(1H-imidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides and derivatives thereof of, which are useful as inhibitors of factor Xa.