21835-63-2

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 4-(3-aminophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester
• CAS NO: 21835-63-2
• Molecular Formula: C17H20N2O4
• Molecular Weight: 316.357
• Mol File: 21835-63-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 4-(3-aminophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 4-(3-aminophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester(21835-63-2)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 4-(3-aminophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester(21835-63-2)

Safety Data

• Hazardous Substances Data: 21835-63-2(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 21881-77-6 m-nifedipine 
• 1709-44-0 m-aminobenzaldehyde 

Downstream Products

• 86880-84-4 1,4-dihydro-4-[3-[isothiocyanato]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester 
• 115746-21-9 1,4-Dihydro-2,6-dimethyl-4-[3-[(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid, dimethyl ester 
• 115746-24-2 2,6-Dimethyl-4-(3-ethoxycarbonylaminophenyl)-3,5-bis(methoxycarbonyl)11,4-dihydropyridine 
• 182621-23-4 1,4-Dihydro-4-[3-[(methoxycarbonyl)amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester 
• 186185-03-5 BMS-193885 
• 182621-24-5 1,4-dihydro-4-(3-isocyanatophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester 

Relevant articles and documents

Synthesis and pharmacological evaluation of novel homocamptothecin- dihydropyridine derivative conjugates as potent topoisomerase i inhibitors

Homocamptothecins (hCPT) represent a new generation of antitumour agents targeting DNA topoisomerase I. The expanded seven-membered lactone E-ring that characterizes hCPT enhances the plasma stability of the drug and reinforces the inhibition of topoisomerase I (Topo I) compared with conventional six-membered CPT. In an attempt to improve the antitumour activity of hCP, a series of novel hCPT derivatives conjugating with dihydropyridine derivates were designed and synthesized based on a synthetic route that couples 7-formylhomocamptothecin with different dihydropyridine derivates. Most of the synthesized compounds exhibited good cytotoxic activity on tumour cell line A549, MDA-MB-435, and HCT116. Furthermore, this class of compounds showed superior Topo I inhibition activity comparable to or higher than CPT. CSIRO 2011.

Chemo- and regioselective reduction of nitroarenes, carbonyls and azo dyes over nickel-incorporated hexagonal mesoporous aluminophosphate molecular sieves

Nickel-incorporated hexagonal mesoporous aluminophosphate (NiHMA) molecular sieves were found to be highly efficient heterogeneous catalysts for the chemo- and regioselective reduction of nitroarenes and carbonyl compounds as well as the reductive cleavage of azo functions, including bulkier substrates, by the hydrogen transfer method.

Regio- and chemoselective catalytic transfer hydrogenation of aromatic nitro and carbonyl as well as reductive cleavage of azo compounds over novel mesoporous NiMCM-41 molecular sieves

(equation presented) Regio-and chemoselective reduction of nitroarenes and carbonyl compounds and reductive cleavage of azo compounds, including bulkier molecules, was achieved by the catalytic transfer hydrogenation method (CTH) using a novel nickel-containing mesoporous silicate (NiMCM-41) molecular sieve catalyst. In addition, the catalyst was also found to behave as a truly heterogeneous catalyst as the yield was practically unaffected.