21840-67-5Relevant articles and documents
But-2-ynylbisoxycarbonyl chloride: A novel C2-symmetric reagent for the protection of amines and amino acids
Ramesh,Chandrasekaran
, p. 4947 - 4950 (2007/10/03)
(Chemical Equation Presented) A novel C2-symmetric protecting group for amines, the but-2-ynylbisoxycarbonyl (Bbc) group, is developed, which can be deblocked with tetrathiomolybdate under neutral conditions. One equivalent of the bischloroformate, BbcCl, is used for the protection of 2 equiv of the amine. Its application in peptide synthesis is established through the synthesis of a tripeptide, and its orthogonality with Cbz, Fmoc, and Boc groups has been studied.