218439-07-7

Upstream product

• 218439-02-2 1-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-prop-2-en-1-ol 
• 218439-01-1 tert-Butyl-((4R,5R)-5-[1,3]dithian-2-yl-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-diphenyl-silane 
• 218439-03-3 tert-Butyl-[(4R,5S)-2,2-dimethyl-5-(1-vinyloxy-allyl)-[1,3]dioxolan-4-ylmethoxy]-diphenyl-silane 
• 218439-30-6 (1R,2R)-3-(tert-Butyl-diphenyl-silanyloxy)-1-[1,3]dithian-2-yl-propane-1,2-diol 
• 105368-84-1 4-O-[(tert-butyl)diphenylsilyl]-2,3-O-isopropylidene-D-erythrose 
• 218439-05-5 (E)-5-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-pent-4-enal 

Downstream Products

• 218439-35-1 [(4R,5S)-5-((E)-5-Benzyloxymethoxy-pent-1-enyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy]-tert-butyl-diphenyl-silane 
• 218439-31-7 tert-Butyl-{(4R,5S)-5-[(E)-5-(4-methoxy-benzyloxy)-pent-1-enyl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy}-diphenyl-silane 
• 218439-09-9 (4S,5S)-5-((E)-5-Benzyloxymethoxy-pent-1-enyl)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 218439-36-2 [(4R,5S)-5-((E)-5-Benzyloxymethoxy-pent-1-enyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methanol 
• 218439-32-8 {(4R,5S)-5-[(E)-5-(4-Methoxy-benzyloxy)-pent-1-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 
• 218439-33-9 Toluene-4-sulfonic acid (4R,5S)-5-[(E)-5-(4-methoxy-benzyloxy)-pent-1-enyl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 

Relevant academic research and scientific papers

Synthetic study on a 26-membered macrolide, amphidinolide B: Synthesis of the C1-C13 fragment

The C1-C13 fragment of amphidinolide B (1) was synthesized from D-erythrose (3). The Evans alkylation reaction protocol allowed the introduction of the stereogenic center at the CM position, which was unambiguously confirmed by a single X-ray crystallographic analysis.