21844-68-8Relevant academic research and scientific papers
A mild method for the cleavage of the 4-picolyloxy group with magnesium under neutral conditions
Zhu, Jianwei,Miao, Wenjun,Bao, Lingling,Ji, Tao,Tang, Guo,Xu, Pengxiang,Zhao, Yufen
supporting information; experimental part, p. 142 - 144 (2012/02/04)
A mild and efficient method for the selective hydrolysis of 4-picolyl esters with magnesium in methanol or water in the presence of other esters and sensitive protecting groups is described. 4-Picolyl aryl ethers and thioethers are also smoothly deprotected to give the corresponding phenols and thiophenols. Georg Thieme Verlag Stuttgart. New York.
Broadening of the substrate tolerance of α-chymotrypsin by using the carbamoylmethyl ester as an acyl donor in kinetically controlled peptide synthesis
Miyazawa, Toshifumi,Tanaka, Kayoko,Ensatsu, Eiichi,Yanagihara, Ryoji,Yamada, Takashi
, p. 87 - 93 (2007/10/03)
In the kinetically controlled approach of peptide synthesis mediated by α-chymotrypsin, the broadening of the protease's substrate tolerance is achieved by switching the acyl donor from the conventional methyl ester to the carbamoylmethyl ester. Thus, as a typical example, the extremely low coupling efficiency obtained by employing the methyl ester of an inherently poor amino acid substrate, Ala, is significantly improved by the use of this particular ester. Its ameliorating effect is observed also in the couplings of other amino acid residues such as Gly and Ser as carboxy components.
2,2'-CARBONYL-BIS(3,5-DIOXO-4-METHYL-1,2,4-OXADIAZOLIDINE) : II- REAGENT FOR THE DIRECT ESTERIFICATION OF CARBOXYLIC ACIDS.
Grenouillat, Denis,Senet, Jean-Pierre,Sennyey, Gerard
, p. 5827 - 5828 (2007/10/02)
Reaction of carboxylic acids including N-protected α-amino acids with 2,2'-carbonyl bis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) and alcohols affords the corresponding esters under mild conditions.
