218457-71-7 Usage
Uses
Used in Pharmaceutical Research and Development:
BOC-D-3,4-DIMETHOXYPHENYLALANINE is used as a key component in the synthesis of peptide-based compounds for the development of new pharmaceutical drugs. Its unique structure and properties contribute to the design and optimization of therapeutic agents with specific biological activities.
Used in Biochemical Studies:
In the field of biochemistry, BOC-D-3,4-DIMETHOXYPHENYLALANINE is utilized as a research tool to investigate the structure, function, and interactions of peptides and proteins. Its incorporation into peptide sequences allows for the exploration of novel biochemical pathways and mechanisms.
Used in Drug Design and Synthesis:
BOC-D-3,4-DIMETHOXYPHENYLALANINE is employed as a building block in the design and synthesis of drug candidates with specific therapeutic targets. Its unique chemical properties enable the development of drugs with improved pharmacokinetic and pharmacodynamic profiles.
Used in Peptide Synthesis:
In the synthesis of peptides, BOC-D-3,4-DIMETHOXYPHENYLALANINE is used as a protected amino acid to facilitate the stepwise assembly of peptide chains. The BOC protecting group ensures the selective incorporation of the 3,4-dimethoxyphenylalanine residue during the synthesis process, allowing for the production of complex peptide structures with desired biological activities.
Overall, BOC-D-3,4-DIMETHOXYPHENYLALANINE is a versatile compound with a wide range of applications in the fields of pharmaceutical research, biochemistry, drug design, and peptide synthesis. Its unique properties and potential in the development of new therapeutic agents make it an important tool for researchers and scientists working in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 218457-71-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,4,5 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 218457-71:
(8*2)+(7*1)+(6*8)+(5*4)+(4*5)+(3*7)+(2*7)+(1*1)=147
147 % 10 = 7
So 218457-71-7 is a valid CAS Registry Number.
218457-71-7Relevant articles and documents
Discovery of pyrrolopyrimidine inhibitors of Akt
Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.
scheme or table, p. 5607 - 5612 (2010/11/17)
The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts.