21857-45-4

Basic information

• Product Name: 5-Methoxy-2,3-dihydroindoline
• Synonyms: 1H-INDOLE, 2,3-DIHYDRO-5-METHOXY-;5-METHOXYLINDOLINE;5-METHOXY-2,3-DIHYDRO-1H-INDOLE;5-METHOXY-2,3-DIHYDROINDOLINE;5-Methoxyindoline;5-Methoxy-2,3-dihydro-1H-indoline
• CAS NO: 21857-45-4
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• Product Categories: pharmacetical;Indoline & Oxindole
• Mol File: 21857-45-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 282.649 °C at 760 mmHg
• Flash Point: 105.954 °C
• Appearance: /
• Density: 1.077 g/cm₃
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.07±0.20(Predicted)
• CAS DataBase Reference: 5-Methoxy-2,3-dihydroindoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-2,3-dihydroindoline(21857-45-4)
• EPA Substance Registry System: 5-Methoxy-2,3-dihydroindoline(21857-45-4)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 21857-45-4(Hazardous Substances Data)

Usage

General Description

5-Methoxy-2,3-dihydroindoline is a chemical compound with the molecular formula C9H11NO and a molar mass of 149.19 g/mol. It is a derivative of indoline, a bicyclic organic compound. 5-Methoxy-2,3-dihydroindoline is a colorless to pale yellow liquid at room temperature and is soluble in organic solvents. 5-Methoxy-2,3-dihydroindoline is used as a building block in the synthesis of pharmaceutical compounds and agrochemicals, as well as in the production of dyes and pigments. It is also employed as a precursor in the manufacturing of various fine chemicals. Additionally, it has demonstrated potential biological activities, making it a target for further research and development in the pharmaceutical industry.

InChI:InChI=1/C9H11NO/c1-11-8-2-3-9-7(6-8)4-5-10-9/h2-3,6,10H,4-5H2,1H3

Upstream product

• 1006-94-6 5-methoxylindole 

Downstream Products

• 1006-94-6 5-methoxylindole 
• 62-53-3 aniline 
• 108-69-0 3,5-dimethylaminoaniline 
• 87-62-7 2,6-dimethylaniline 
• 14073-22-4 4-(5-methoxy-1H-indol-3-yl)butan-2-one 
• 16382-21-1 1-benzyl-5-methoxyindole 
• 138469-78-0 5-methoxy-3-(phenylmethyl)-1H-indole 
• 46182-32-5 1-ethyl-5-methoxy-1H-indole 

Relevant articles and documents

Organometallic Synthesis of Bimetallic Cobalt-Rhodium Nanoparticles in Supported Ionic Liquid Phases (CoxRh100?x@SILP) as Catalysts for the Selective Hydrogenation of Multifunctional Aromatic Substrates

The synthesis, characterization, and catalytic properties of bimetallic cobalt-rhodium nanoparticles of defined Co:Rh ratios immobilized in an imidazolium-based supported ionic liquid phase (CoxRh100?x@SILP) are described. Following an organometallic approach, precise control of the Co:Rh ratios is accomplished. Electron microscopy and X-ray absorption spectroscopy confirm the formation of small, well-dispersed, and homogeneously alloyed zero-valent bimetallic nanoparticles in all investigated materials. Benzylideneacetone and various bicyclic heteroaromatics are used as chemical probes to investigate the hydrogenation performances of the CoxRh100?x@SILP materials. The Co:Rh ratio of the nanoparticles is found to have a critical influence on observed activity and selectivity, with clear synergistic effects arising from the combination of the noble metal and its 3d congener. In particular, the ability of CoxRh100?x@SILP catalysts to hydrogenate 6-membered aromatic rings is found to experience a remarkable sharp switch in a narrow composition range between Co25Rh75 (full ring hydrogenation) and Co30Rh70 (no ring hydrogenation).