218608-81-2 Usage
General Description
(S)-3-AMINO-5,5-DIMETHYLHEXANOIC ACID, also known as ambroxol, is an organic compound classified as an amino acid derivative. It is commonly utilized in the pharmaceutical industry as a mucolytic agent, aiding in the breakdown of mucus and facilitating its removal from the respiratory tract. Ambroxol is also used as an active ingredient in expectorant medications to help treat conditions such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD). Its chemical structure includes an amino group and a hexanoic acid moiety, which contribute to its therapeutic properties. Ambroxol has demonstrated efficacy in promoting mucociliary clearance and reducing cough frequency, making it a valuable component in respiratory medications. Additionally, it has been studied for its potential anti-inflammatory and antioxidant effects.
Check Digit Verification of cas no
The CAS Registry Mumber 218608-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,6,0 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 218608-81:
(8*2)+(7*1)+(6*8)+(5*6)+(4*0)+(3*8)+(2*8)+(1*1)=142
142 % 10 = 2
So 218608-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H17NO2/c1-8(2,3)5-6(9)4-7(10)11/h6H,4-5,9H2,1-3H3,(H,10,11)/t6-/m1/s1
218608-81-2Relevant articles and documents
Enantioselective, chromatography-free synthesis of β3-Amino acids with natural and unnatural side chains
Gerfaud, Thibaud,Chiang, Ying-Ling,Kreituss, Imants,Russak, Justin A.,Bode, Jeffrey W.
, p. 687 - 696 (2012/07/13)
β3-Amino acids are key components of some pharmaceuticals, excellent surrogates for metabolically labile α-amino acids, and building blocks for chiral heterocycles. Unfortunately they are not easily accessible in enantiomerically pure form, especially when possessing unnatural side chains. A flexible, chromatography-free process for the synthesis of enantiopure β3-amino acids possessing natural and unnatural side chains is described. The procedure uses inexpensive starting materials and reagents and offers a good alternative to the hazardous and expensive Arndt-Eistert homologation of enantiopure α-amino acids. Its utility has been demonstrated with the preparative scale synthesis of two valuable β3-amino acids possessing unnatural side chains.
An enantiospecific synthesis of β-amino acids
Jefford,Wang
, p. 1111 - 1114 (2007/10/02)
L-Aspartic acid by regioselective modification of the α-carboxylic acid group, namely N-tosylation, anhydride formation, reduction, iodo-esterification, alkylation, and deprotection afforded a series of γ-alkyl β-aminobutyric acids of the R configuration (ee > 99%).
