218608-99-2 Usage
Uses
Used in Pharmaceutical Development:
BOC-(S)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID is used as a chemical intermediate for the synthesis of complex molecules and drugs, contributing to the advancement of pharmaceutical research and development.
Used in Chemical and Biological Experiments:
In the fields of chemistry and biochemistry, BOC-(S)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRIC ACID is used as a reagent in various chemical and biological experiments, facilitating the exploration of new chemical reactions and biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 218608-99-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,6,0 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 218608-99:
(8*2)+(7*1)+(6*8)+(5*6)+(4*0)+(3*8)+(2*9)+(1*9)=152
152 % 10 = 2
So 218608-99-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H20FNO4/c1-15(2,3)21-14(20)17-11(9-13(18)19)8-10-6-4-5-7-12(10)16/h4-7,11H,8-9H2,1-3H3,(H,17,20)(H,18,19)/t11-/m0/s1
218608-99-2Relevant academic research and scientific papers
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
