218632-26-9Relevant academic research and scientific papers
Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase
Haque, Tasir S.,Tadesse, Seifu,Marcinkeviciene, Jovita,Rogers, M. John,Sizemore, Christine,Kopcho, Lisa M.,Amsler, Karen,Ecret, Lisa D.,Zhan, Dong Liang,Hobbs, Frank,Slee, Andrew,Trainor, George L.,Stern, Andrew M.,Copeland, Robert A.,Combs, Andrew P.
, p. 4669 - 4678 (2007/10/03)
The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach is described below. The initial pyrazole-containing lead compounds were optimized for potency against Helicobacter pylori DHODase. Using three successive focused libraries, inhibitors were rapidly identified with the following characteristics: Ki 10 000-fold selectivity over human DHODase.
INHIBITORS OF FACTOR XA WITH A NEUTRAL P1 SPECIFICITY GROUP
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, (2008/06/13)
The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: STR1 or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as methoxy and halo.
