21868-41-7

Basic information

• Product Name: 4-(chloromethyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine
• Synonyms: 4-(chloromethyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine;AKOS VGYB0001230;TIMTEC-BB SBB001690;4-(chloromethyl)-6-morpholin-4-yl-1,3,5-triazin-2-amine;1,3,5-triazin-2-amine, 4-(chloromethyl)-6-(4-morpholinyl)-;[4-(chloromethyl)-6-morpholino-s-triazin-2-yl]amine;2-Amino-4-(chloromethyl)-6-morpholino-s-triazine;4-(chloromethyl)-6-morpholino-1,3,5-triazin-2-amine
• CAS NO: 21868-41-7
• Molecular Formula: C8H12ClN5O
• Molecular Weight: 229.67
• Mol File: 21868-41-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 480.7°C at 760 mmHg
• Flash Point: 244.5°C
• Appearance: /
• Density: 1.414g/cm³
• Vapor Pressure: 2.12E-09mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 4-(chloromethyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(chloromethyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine(21868-41-7)
• EPA Substance Registry System: 4-(chloromethyl)-6-(4-morpholinyl)-1,3,5-triazin-2-amine(21868-41-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21868-41-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12ClN5O/c9-5-6-11-7(10)13-8(12-6)14-1-3-15-4-2-14/h1-5H2,(H2,10,11,12,13)

Upstream product

• 3731-59-7 moroxydine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 22362-16-9 4-morpholin-4-yl-6-phenylsulfanylmethyl-[1,3,5]triazin-2-ylamine 
• 22362-15-8 4-benzylsulfanylmethyl-6-morpholin-4-yl-[1,3,5]triazin-2-ylamine 
• 21868-52-0 1-(4-amino-6-morpholin-4-yl-[1,3,5]triazin-2-ylmethyl)-4-benzoyl-piperazine 
• 30146-77-1 4-(cyclohexylamino-methyl)-6-morpholin-4-yl-[1,3,5]triazin-2-ylamine 
• 30146-76-0 6,6'-di-morpholin-4-yl-4,4'-(2-cyclohexyl-2-aza-propane-1,3-diyl)-bis-triazin-2-ylamine 
• 21921-65-3 4-(4-benzyl-piperazin-1-ylmethyl)-6-morpholin-4-yl-[1,3,5]triazin-2-ylamine 
• 30146-59-9 4-(4-amino-6-morpholin-4-yl-[1,3,5]triazin-2-ylmethyl)-piperazine-1-carboxylic acid diethylamide 
• 21868-47-3 4-morpholin-4-yl-6-(4-phenyl-piperazin-1-ylmethyl)-[1,3,5]triazin-2-ylamine 
• 30146-60-2 4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-6-morpholin-4-yl-[1,3,5]triazin-2-ylamine 

Relevant articles and documents

Synthesis, structural characterization and antitumor activity of novel 2,4-diamino-1,3,5-triazine derivatives

The syntheses, structural elucidation based on NMR spectroscopy and X-ray analysis of 8 as well as antitumor activities of novel 2,4-diamino-1,3,5-triazine derivatives 5 and 7-22 are described. Screenings performed at NCI showed that most derivatives possessed a moderate to strong growth inhibition activity on various tumor panel cell lines between 0.148 and 56.2 μM concentrations. 2-Amino-6-bromomethyl-4-(3,5,5-trimethyl-2-pyrazoline)-l,3,5-triazine 11 showed the most potent antitumor activity with the mean midpoint values of log10 GI50, log10 TGI50 and log10 LC50 of all tests equal to -5.26, -4.81 and -4.37, respectively and therefore, it can be considered as a lead structure for further development of anticancer agents.