218767-48-7Relevant academic research and scientific papers
Synthetic studies on mitotic kinesin Eg5 inhibitors: Synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives
Yamamoto, Junichiro,Amishiro, Nobuyoshi,Kato, Kazuhiko,Ohta, Yoshihisa,Ino, Yoji,Araki, Mitsuharu,Tsujita, Tetsuya,Okamoto, Seiho,Takahashi, Takeshi,Kusaka, Hideaki,Akinaga, Shiro,Yamashita, Yoshinori,Nakai, Ryuichiro,Murakata, Chikara
, p. 3961 - 3963 (2014/09/17)
The 2,4,5-substituted-1,3,4-thiadiazoline derivative 1a has been identified as a new class of mitotic kinesin Eg5 inhibitor. With the aim of enhancement of the mitotic phase accumulation activity, structure optimization of side chains at the 2-, 4-, and 5
