218785-35-4

Upstream product

• 218785-10-5 (1R,3R,4R)-1-[(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-1-methoxy-4-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentan-3-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 218785-33-2 (1R,4S)-1-[(2S,3S,5S,7R,8S,9S)-7-(2-Benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-1-methoxy-4-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-pentan-3-one 
• 254893-88-4 (2S,3S,4R)-6-Benzyloxy-1-{2-[(2S,3S)-3-hydroxy-2-(4-methoxy-benzyloxy)-1,1-dimethyl-pent-4-enyl]-[1,3]dithian-2-yl}-3-methyl-hexane-2,4-diol 
• 137765-35-6 (4R,5S,6R)-4-(2-Benzyloxy-ethyl)-6-iodomethyl-5-methyl-[1,3]dioxan-2-one 
• 137664-68-7 (3S,4S)-5-{2-[(2S,3S,4R)-6-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-4-(4-methoxy-benzyloxy)-5-methyl-hex-1-en-3-ol 
• 137664-80-3 (S)-3-{2-[(2S,3S,4R)-6-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-butyraldehyde 
• 254893-83-9 (S)-4-(1-{2-[(2S,3S,4R)-6-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-1-methyl-ethyl)-2-(4-methoxy-phenyl)-[1,3]dioxolane 
• 137664-79-0 (S)-3-{2-[(2S,3S,4R)-6-Benzyloxy-2,4-bis-(tert-butyl-dimethyl-silanyloxy)-3-methyl-hexyl]-[1,3]dithian-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-butan-1-ol 
• 254893-81-7 (2S,3R,4R)-6-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-(2-{1-[(S)-2-(4-methoxy-phenyl)-[1,3]dioxolan-4-yl]-1-methyl-ethyl}-[1,3]dithian-2-yl)-3-methyl-hexan-2-ol 
• 254893-78-2 (S)-4-(1-[1,3]Dithian-2-yl-1-methyl-ethyl)-2-(4-methoxy-phenyl)-[1,3]dioxolane 
• 137664-69-8 [(1R,2R)-1-(2-Benzyloxy-ethyl)-2-(R)-oxiranyl-propoxy]-tert-butyl-dimethyl-silane 
• 137664-74-5 (3R,4S)-1-Benzyloxy-4-(R)-oxiranyl-pentan-3-ol 
• 137664-75-6 2-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-2-methyl-propionaldehyde 

Downstream Products

• 218785-37-6 C₆₁H₁₀₈O₁₁Si₃ 
• 218785-18-3 C₆₃H₁₂₅O₁₃PSi₅ 
• 218785-39-8 2,2-dimethyl-propionic acid 7-[7-(2-benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-2,4-dimethyl-heptyl ester 
• 254894-52-5 2,2-Dimethyl-propionic acid (2S,3S,4R,5R,7R)-7-[(2S,3S,5S,7R,8S,9S)-7-(2-benzyloxy-ethyl)-9-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-4,4,8-trimethyl-1,6-dioxa-spiro[4.5]dec-2-yl]-3,5-dihydroxy-7-methoxy-2,4-dimethyl-heptyl ester 

Relevant academic research and scientific papers

Total synthesis of (+)-calyculin A and (-)-calyculin B: Asymmetric synthesis of the C(9-25) spiroketal dipropionate subunit

An asymmetric synthesis of the stereochemically fully endowed C(9-25) spiroketal fragment (+)-BC of the calyculins (1-8) is described. Highlights of the synthesis include: a highly diastereoselective IBr-induced iodocarbonate cyclization to introduce the