21886-16-8Relevant academic research and scientific papers
Case study of small molecules as antimalarials: 2-amino-1-phenylethanol (APE) derivatives
Chaparro, Mariía J.,Vidal, Jaume,Angulo-Barturen, Ií?igo,Bueno, José M.,Burrows, Jeremy,Cammack, Nicholas,Casta?eda, Pablo,Colmenarejo, Gonzalo,Coteroín, José M.,De Las Heras, Laura,Fernández, Esther,Ferrer, Santiago,Gabarroí, Raquel,Gamo, Francisco J.,Garciía, Mercedes,Jiménez-Diíaz, Mariía B.,Lafuente, Mariía J.,Leoín, Mariía L.,Martiínez, Mariía S.,Minick, Douglas,Prats, Sara,Puente, Margarita,Rueda, Lourdes,Sandoval, Elena,Santos-Villarejo, ángel,Witty, Michael,Calderoín, Félix
supporting information, p. 657 - 661 (2014/07/07)
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4-0.5 ?M are able to show in vivo activity.
Inter- and Intramolecular Cycloadditions of Nitroalkenes with Olefins. 2-Nitrostyrenes
Denmark, Scott E.,Kesler, Brenda S.,Moon, Young-Choon
, p. 4912 - 4924 (2007/10/02)
Aromatic nitroalkenes 9 - 12 underwent Lewis acid catalyzed cycloadditions with various cyclic alkenes to afford high yields of nitronates 25 - 30 with exclusive anti selectivity.Hammett studies helped to further delineate the role of the Lewis acid.Reaction of nitroalkenes 8 and 10 with various cyclic dienes in the presence of a Lewis acid demonstrated the ability of nitroalkenes to behave as dienes in cycloadditions.The major products were the syn diastereomers which arise from an endo-folded transition structure.Finally, intramolecular cycloaddition of 36 - 39 allowed a correlation between the stereochemical course of the reaction and positions of sp2 centers in the tether to be addressed.
