218903-31-2

Basic information

• Product Name: 4-(2,2-dibromovinyl)-2-methoxyphenol
• Synonyms: 4-(2,2-dibromovinyl)-2-methoxyphenol
• CAS NO: 218903-31-2
• Molecular Weight: 307.969
• Mol File: 218903-31-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(2,2-dibromovinyl)-2-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2-dibromovinyl)-2-methoxyphenol(218903-31-2)
• EPA Substance Registry System: 4-(2,2-dibromovinyl)-2-methoxyphenol(218903-31-2)

Safety Data

• Hazardous Substances Data: 218903-31-2(Hazardous Substances Data)

Upstream product

• 558-13-4 carbon tetrabromide 
• 121-33-5 vanillin 
• 200941-14-6 β,β-dibromo-4-isopropoxy-3-methoxystyrene 

Downstream Products

• 742108-74-3 C₂₃H₁₇NO₄ 
• 742108-76-5 C₂₃H₁₇NO₄ 
• 742108-75-4 C₂₃H₂₅NO₄ 
• 742108-77-6 C₂₃H₂₅NO₄ 
• 742108-78-7 C₂₂H₁₆O₄S 

Relevant articles and documents

Synthesis and Photoswitching Properties of Bioinspired Dissymmetric I-Pyrone, an Analogue of Cyclocurcumin

Cyclocurcumin (CC), a turmeric curcuminoid with potential therapeutic properties, is also a natural photoswitch that may undergo E/Z photoisomerization under UV light. To be further exploited in relevant biological applications, photoactivation under near-infrared (NIR) irradiation is required. Such requirement can be met through opportune chemical modifications, by favoring two-photon absorption (TPA) probability. Herein, a general and efficient synthesis of a biomimetic 2,6-disubstituted-δ-pyrone analogue of CC is described, motivated by the fact that molecular modeling previews an order of magnitude increase of its NIR TPA compared to CC. Three retrosynthetic pathways have been identified (i) via an aryl-oxazole intermediate or via aryl-diynone through (ii) a bottom-up or (iii) a top-down approach. While avoiding the passage through unstable synthons or low-yield intermediate reactions, only the latest approach could conveniently afford the 2,6-disubstituted-I-pyrone analogue of CC, in ten steps and with an overall yield of 18%. The photophysical properties of our biomimetic analogue have also been characterized showing an improved photoisomerization yield over the parent natural compound. The potentially improved nonlinear optical properties, as well as enhanced stability, may be correlated to the enforcement of the planarity of the pyrone moiety leading to a quadrupolar D-π-A-π-D system.

Total synthesis of moniliformediquinone and calanquinone A as potent inhibitors for breast cancer

The first synthesis of moniliformediquinone has been achieved in which the longest linear sequence is only nine steps. The synthesis proceeds in 23% overall yield from commercially available 2,4,5-trimethoxybenzaldehyde. The key transformations include a

Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities

Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compo