21891-11-2Relevant academic research and scientific papers
Enantioselective synthesis and cross-coupling of tertiary propargylic boronic esters using lithiation-borylation of propargylic carbamates
Partridge, Benjamin M.,Chausset-Boissarie, Laetitia,Burns, Matthew,Pulis, Alexander P.,Aggarwal, Varinder K.
supporting information, p. 11795 - 11799 (2013/01/15)
Lithiation-borylation of propargylic carbamates leads to tertiary propargylic boronic esters in very high e.r., provided that ethylene glycol boronic esters are used. These versatile intermediates undergo a range of highly stereoselective transformations, including protodeboronation to give tertiary allenes and Suzuki-Miyaura cross-couplings of tertiary boron species leading to tetrasubstituted allenes with high enantiospecificity. Copyright
