218916-52-0

Basic information

• Product Name: DIACETYL BENZOYL LATHYROL
• Synonyms: DIACETYL BENZOYL LATHYROL;(1aR,2E,4aR,6S,7S,7aR,8R,11aS)-4a,8-Bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-4H-cyclopenta[a]cyclopropa[f]cycloundecen-4-one;5,15-Diacetyl-3-benzoyllathyrol;Euphorbia factor L3;Phytoclear EL-1;Lathyrol-3,15-diacetate-5-benzoate;Eupho;Euphporbia factor L3
• CAS NO: 218916-52-0
• Molecular Formula: C31H38O7
• Molecular Weight: 522.634
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 218916-52-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 595.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.19
• CAS DataBase Reference: DIACETYL BENZOYL LATHYROL(CAS DataBase Reference)
• NIST Chemistry Reference: DIACETYL BENZOYL LATHYROL(218916-52-0)
• EPA Substance Registry System: DIACETYL BENZOYL LATHYROL(218916-52-0)

Safety Data

• Hazardous Substances Data: 218916-52-0(Hazardous Substances Data)

Usage

Cytotoxicity

EFL3 of lathyrane diterpenoids showed potent cytotoxicity to A549 cells. Furthermore, EFL3 induced apoptosis of A549 cells through mitochondrial pathway with involvement of loss of ΔΨm, release of cytochrome c. The cytotoxicity of EFL3 was determined by an MTT assay to evaluate its antitumor activity. The results showed that EFL3 inhibited cell proliferation in a concentration-dependent manner in A549 cells after 72 h treatment. The IC50 of EFL3 for A549 cells was 34.04 ± 3.99 μM. The data suggested that EFL3 exhibited potent cytotoxicity towards these cells. The results showed that EFL3 showed more potent cytotoxicity to A549 cellsMolecules 2011, 16 3225 than EFL1 (P < 0.01).

Uses

Lathyrol-3,15-diacetate-5-benzoate could induce apoptosis in lung cancer A549 cells through the mitochondrial pathway including the loss of mitochondrial potential and release of cytochrome c.