21892-75-1

Upstream product

• 10152-76-8 allylmethyl sulfide 

Downstream Products

• 16215-14-8 allyl methyl sulfone 
• 10152-76-8 allylmethyl sulfide 
• 14094-08-7 methyl n-propyl sulfoxide 

Relevant academic research and scientific papers

In vivo metabolism of diallyl disulphide in the rat: Identification of two new metabolites

1. Diallyl disulphide (DADS), a compound formed from the organosulphur compounds present in garlic, is known for its anticarcinogenic effects in animal models. 2. The aim was to identify and analyse the metabolites produced in vivo after a single oral administration of 200mgkg-1 DADS to rats. The organic sulphur metabolites present in the stomach, liver, plasma and urine were measured by gas chromatography coupled with mass spectrometry over 15 days. 3. Data indicate that DADS is absorbed and transformed into allyl mercaptan, allyl methyl sulphide, allyl methyl sulphoxide (AMSO) and allyl methyl sulphone (AMSO2), which are detected throughout the excretion period. Overall, the highest amounts of metabolites were measured 48-72 h after the DADS administration. AMSO2 is the most abundant and persistent of these compounds. The levels of all the sulphur compounds rapidly decline within the first week after administration and disappear during the second week. Only AMSO and AMSO2 are significantly excreted in urine. 4. These potential metabolites are thought to be active in the target tissues. Our data warrant further studies to check this hypothesis.

Air atmospheric photocatalytic oxidation by ultrathin C,N-TiO2nanosheets

Herein, we demonstrate the highly efficient photocatalytic sulfide oxidation reaction under mild conditions,i.e.in air, at room temperature and in the absence of a sacrificial reagent, co-catalyst or redox mediator, by using ultrathin C,N-TiO2nanosheets as a photocatalyst.

[MoO3(2,2″–bipy)]n catalyzed oxidation of amines and sulfides

The polymeric catalyst [MoO3(2,2′–bipy)]n has been employed in the oxidation of secondary amines to nitrones, and sulfides to sulfoxides or sulfones, using tert–butylhydroperoxide (TBHP) as the stoichiometric oxidant. Whereas the oxi

Controlled oxidation of organic sulfides to sulfoxides under ambient conditions by a series of titanium isopropoxide complexes using environmentally benign H2O2 as an oxidant

Controlled oxidation of organic sulfides to sulfoxides under ambient conditions has been achieved by a series of titanium isopropoxide complexes that use environmentally benign H2O2 as a primary oxidant. Specifically, the [N,N′-bis(2-oxo-3-R1-5-R2- phenylmethyl)-N,N′-bis(methylene-R3)-ethylenediamine]Ti(O iPr)2 [R1 = t-Bu, R2 = Me, R 3 = C7H5O2 (1b); R1 = R2 = t-Bu, R3 = C7H5O2 (2b); R1 = R2 = Cl, R3 = C7H 5O2 (3b) and R1 = R2 = Cl, R 3 = C6H5 (4b)] complexes efficiently catalyzed the sulfoxidation reactions of organic sulfides to sulfoxides at room temperature within 30 min of the reaction time using aqueous H2O 2 as an oxidant. A mechanistic pathway, modeled using density functional theory for a representative thioanisole substrate catalyzed by 4b, suggested that the reaction proceeds via a titanium peroxo intermediate 4c′, which displays an activation barrier of 22.5 kcal mol-1 (ΔG?) for the overall catalytic cycle in undergoing an attack by the S atom of the thioanisole substrate at its σ*-orbital of the peroxo moiety. The formation of the titanium peroxo intermediate was experimentally corroborated by a mild ionization atmospheric pressure chemical ionization (APCI) mass spectrometric technique. The Royal Society of Chemistry 2010.

Oxidation of thioethers and sulfoxides with hydrogen peroxide using TS-1 as catalyst

A combined experimental and molecular simulation study of the oxidation of thioethers with H2O2 was conducted using titanium-containing zeolites as catalysts. Regioselectivity was investigated for the oxidation of allyl methyl thioether using TS-1 as catalyst. Only products for the oxidation of sulfur, such as sulfoxide and sulfolane, were found. Shape-selective oxidation was studied with four isomeric butyl methyl thioethers. For n-, iso-, and sec-butyl methyl thioethers, the principal product for the TS-1 catalyzed reaction was the sulfone, but that for tert-butyl methyl thioether was from partial oxidation to sulfoxide. The origin of this effect was evaluated using molecular simulations. Thioether oxidation to sulfoxide readily occurred via a non-catalyzed solution reaction, while the oxidation of sulfoxide to sulfone was only observed in the catalyzed reactions. The non-catalyzed reaction can be suppressed by conducting the catalyzed reaction in the presence of a base, 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), that is too large to diffuse into the intracrystalline pore structure of TS-1. With DBU, the reaction rate with TS-1 as catalyst was much lower. The relative ratios of the sulfoxide and sulfone products can be elucidated through intramolecular steric hindrance and the shape selectivity of the zeolite. TS-1 has been used for the oxidation of alkenes, alcohols, allylic alcohols, phenols, and benzene.